For many people, the ability to see clearly is something that is often taken for granted. But imagine living your entire life with limited vision, watching the world through a small straw hole. This has been a reality for college student Olivia Cook, who was born with an inherited retinal disorder known as Leber congenital amaurosis (LCA).
LCA is a rare type of eye disorder that causes blindness, making it difficult for individuals to see people’s faces and details in dimly lit places. However, Cook’s life took a hopeful turn when she decided to participate in a clinical trial involving an experimental gene-editing treatment using CRISPR.
CRISPR-Cas9 gene editing has been making waves in the scientific community due to its potential to treat genetic disorders. In Cook’s case, this groundbreaking technology was used to correct the form of inherited blindness caused by LCA.
The results of the Phase 1/2 clinical trial showed promising outcomes for Cook and other participants. Among a total of 14 volunteers, including Cook, most experienced significant improvement in their vision about three months after receiving the experimental treatment.
“The therapy remains experimental and the results need to be replicated in a larger group of people”.
-CNN
A few patients even reported being able to differentiate colors, read text on screens, and appreciate visual details they had never seen before.
Efficacy did not correlate with dose size but seems also remarkable: Among adults according dosis assigned two were given low dosage,
five were given intermediate dose while five were assigned higher ones however both kids volunteers received intermediate potency.
Per Dr.Eric Pierce findings state:
“The subjects get an injection under their retina which cuts out mutated mutation from genome; once working inside those retinal cells it allows the gene to be restored”. -CNN
Although these results are incredibly promising, it’s important to note that complete vision restoration has not been achieved for all participants. Most of them still can’t read lines of letters or numbers on an eye chart. However, the fact that improvement was observed is a significant breakthrough in treating inherited retinal degenerations caused by CEP290 gene mutations. These types of genetic disorders currently do not have any approved treatments.
The potential of CRISPR-Cas9 gene editing technologies extends far beyond inherited retinal disorders. Researchers hope that this success will pave the way for exploring therapeutic use of CRISPR in other genetic diseases as well.
Finding answers.
“Could a cut in the genome be made 10 years from now, that could have an adverse effect over time? I think the answer to is yes, it could,” – Dr.Eric Pierce
While researchers acknowledge that long-term effects and safety remain important considerations for using CRISPR-Cas9 gene editing tools, they remain hopeful that further studies will shed light on their potential negative impacts.
The successful completion of this Phase 1/2 trial provides a building block for future research in developing effective treatments for various eye disorders.”This experiment is a huge reminder that quality-of-life matters.” -Art Caplan
The societal impact
It’s true that when discussing innovative medical interventions like gene therapies and CRISPR-based treatments, saving lives often takes center stage. However, this study reminds us all about the importance of improving quality-of-life as well.
“This success story with Olivia makes one realize how someone who was living with some sight and had adapted was able to see without being able to see before,” Art Kaplan says.
Quality-of-life improvements can radically change individuals’ experiences and provide hope where previously there might have been none.
However, it’s crucial to keep in mind that more research is needed to determine the sustainability and impact of these improvements in the long term. Dr. Aliaa Abdelhakim highlights this by stating, “We don’t know if improvements from this treatment are going to be sustained. Is their vision going to stay improved throughout their lives?”
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The Dangers of Leaving a Glass of Water Next to Your Bed
Did you know?! Do not place glasses next to the bed.
Many people like to leave a glass of water next to their bed to drink the next morning. But this can be a very dangerous habit, often without realizing it.
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Dirt and insects enter
Mosquitoes, flies and other insects can land or fall into a glass of water if you leave it next to your bed overnight. Dust may fall into the water. And when you accidentally drink it every morning, it is not good for your health.
The water changes taste
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Tap water often contains chlorine. which is a substance added to kill germs Chlorine begins to evaporate at night. As a result, the taste of the water changes. Therefore, drinking a glass of water at night may make you find that the water tastes slightly different and smells bad.
drinking bacteria
When you sip water, millions of bacteria are transferred from your mouth to the glass and then to the water. So if you drink the water in that glass and leave it overnight and then drink it again in the morning. The growing bacteria quickly invade your body and continue to multiply.
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Risk of electric shock and fire.
Beds are often placed near electrical outlets or charging devices like phones, so if you leave a glass of water on your bedside table and accidentally spill it, the water could spill out and come into contact with electronic equipment. and may be at risk of electric shock. This can cause a fire.
The water tastes different.
Leaving it overnight can cause the water to absorb a small amount of carbon dioxide. This changes the pH balance, so the water in your cup may be more acidic with a lower pH. This does not affect your health, but can change the taste of the water and make it less drinkable.
sleep disorders
If you constantly see a glass of water in your vision Especially if you have trouble sleeping. You might take a drink in the middle of the night and have to go to the bathroom. Going to the bathroom multiple times during the night can disrupt your sleep cycle. This causes insomnia and tiredness in the morning.
#place #glasses #bed #ROOM #CHANNEL
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Maximum limits of phytosanitary residues, operational guidelines for the adaptation of the products under review
On 22 and 23 April 2024, during the meeting of the Permanent Committee on Residues on plants, animals, food and feed – pesticide residues section held via video conference, the following draft regulations were voted on:
Document PLAN/2024/791 Rev.4 Document PLAN/2023/138 Rev.9 Document PLAN/2022/2853 Rev.11 Document PLAN/2023/2900 Rev.2 Document PLAN/2023/1960 Rev.4 Document PLAN/2023/ 2190 Rev.3 Document PLAN/2024/817 Rev.4
The transposition of these documents into the respective regulations is currently underway which will modify Annexes I, II, III, IV and V of Regulation (EC) no. 396/2005 of the European Parliament and of the Council regarding maximum residue limits (MRLs) of certain active substances. The regulations will be published shortly in the Official Journal of the European Union.
It is therefore necessary to review the uses currently authorized in Italy for plant protection products containing the active substances subject to modification, to evaluate their compliance with the new MRL values.
The General Directorate for Hygiene, Food Safety and Nutrition (formerly DGISAN – Office 7 – Safety and regulation of plant protection products) previously addressed to companies and trade associations the note dated 06/05/2024, regarding the operational guidelines for the adaptation of the plant protection products under review.
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