Creatine Use Linked to Enhanced Cognitive Function During Sleep Deprivation
Unlocking the Potential of Creatine: From Physical Performance Enhancer to Cognitive Booster
Recent research conducted by experts at Forschungszentrum Jülich has shed light on a fascinating aspect of creatine, a widely popular supplement primarily known for its positive impact on physical performance. The study, published in Scientific Reports, reveals that creatine can also temporarily enhance cognitive abilities affected by sleep deprivation.
Promising Results: Improved Processing Capacity and Short-Term Memory
In the study, 15 test subjects were intentionally deprived of sleep overnight while performing cognitive tasks. This deprivation triggers changes in brain metabolism that facilitate the cellular uptake of creatine. Prior to testing, participants received a high single dose of creatine–a key metabolic product present in certain foods and produced naturally by the body itself. The findings demonstrated positive effects on both brain metabolism and cognitive performance just three hours after ingestion. These effects continued to intensify over a four-hour period, peaking at approximately nine hours post-creatine consumption. Notably, improvements were most significant in processing capacity and short-term memory.
“The results suggest that a single but high dose of creatine enhances thinking capacity and causes changes in the brain’s energy reserves during sleep deprivation,” explains study coordinator Dr. Ali Gordjinejad from the Institute of Neuroscience and Medicine (INM-2) at Forschungszentrum Jülich.
The Potential Dangers: Excessive Intake Warning
While other studies have already reported enhanced cognitive performance with extended use of creatine supplements, this investigation focuses on shorter-term effects brought about by acute ingestions during periods of restricted sleep. It was previously challenging to prove such short-term impacts due to the limited capacity of neuronal cells in the central nervous system (CNS) to absorb creatine. Typically, CNS cells rely heavily on synthesizing their own creatine. However, by intentionally inducing a “stressed” state in the brain through experimental conditions, the researchers successfully fostered increased cellular uptake of creatine.
Dr. Gordjinejad emphasizes caution concerning excessive creatine consumption, stating that high doses place undue strain on kidney function and can pose health risks. However, if subsequent investigations reveal cognitive benefits at lower doses, creatine may well emerge as a formidable alternative to coffee for individuals enduring extended periods of wakefulness.
In conclusion, Forschungszentrum Jülich’s study demonstrates a new dimension of creativity–creativity beyond physical performance enhancement alone. The potential cognitive benefits warrant further exploration and could potentially pave the way for groundbreaking applications in fields like neurology and sleep medicine.
Sources:
- Forschungszentrum Jülich
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Reflecting on Albirex Niigata’s Match Against Vissel Kobe: Players’ Post-Match Comments
[Mobazeko]Comments from the players after the match on May 6 (Monday, public holiday) against Vissel Kobe
Today we would like to bring you comments from Yuji Ono and Souya Fujiwara.
MobaTo theZoriginalKoAlbirex Niigata’s Public Relations Department addressed the players directly after the match with the message “Mobazeco”. This is content that lets you look back on the game, the feelings you had, and sometimes your frustrations, via text!
FW No.99 Yuji Ono
—How do you consider today’s results?
First of all, I am very sorry that we could not deliver the victory to the fans, as many of them came to our visiting team today.
—I think we struggled to get going in the first half.
Even though the opposition defense was compact, there were moments when they put the ball too much into the compact area. We have to make plays that break the opponent’s arrows a little more and that go against the opponent. Also, I think there are always moments during the 90 minutes when it’s not our moment, and personally I think we concede a lot of goals in those moments lately. We need to work harder as a team to find ways to make the most of our time without conceding during those difficult periods. If we score in a difficult period, we will have to start from behind when our time comes, so we have to improve on that.
—To overcome this situation did you play deep in your half of the pitch?
era. However, I didn’t think it would be good for both of us to lose too much, so I told Takashi (Suzuki) to stay in front. Mr. Takashi also thought about it, Hello.
#MobazecoComments #players #match #Monday #public #holiday #Vissel #Kobe #Mobile #Albirex
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Reflecting on Albirex Niigata’s Match Against Vissel Kobe: Players’ Post-Match Comments
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New Genetic Form of Alzheimer’s Disease Discovered by Spanish Researchers
A groundbreaking study led by researchers from the Sant Pau Research Institute in Barcelona has revealed a new genetic form of Alzheimer’s disease. The study, published in ‘Nature Medicine’, highlights the significant impact of the ApoE4 gene on the development of the disease.
The research team, led by Juan Fortea, director of the Memory Unit of the Neurology Service at the institute, found that individuals with two copies of the ApoE4 gene, known as ApoE4 homozygotes, are at a significantly higher risk of developing Alzheimer’s. Over 95% of individuals over the age of 65 with two copies of the gene exhibited biological features of Alzheimer’s in the brain or biomarkers of the disease in cerebrospinal fluid and PET scans.
Fortea explains, “Having two copies of the ApoE4 gene could represent a new genetic form of Alzheimer’s disease. This discovery is crucial as it affects a small but significant portion of the population.”
The researchers analyzed data from over 3,000 brain donors, including samples from 273 ApoE4 homozygotes, to assess the Alzheimer’s risk in individuals with this genetic variant. The results showed that virtually all ApoE4 homozygotes exhibited signs of Alzheimer’s disease by age 55, with abnormal levels of amyloid protein in the cerebrospinal fluid and positive amyloid PET scans.
The implications of this study are significant, suggesting that the ApoE4 genetic variant may not only be a risk factor for Alzheimer’s but could represent a distinct genetic form of the disease. This finding could lead to the development of personalized prevention strategies and targeted therapeutic approaches for individuals with two copies of the gene.
Víctor Montal, a researcher involved in the study, emphasizes the importance of monitoring ApoE4 homozygotes from an early age for preventive interventions. The research opens up new possibilities for understanding and treating Alzheimer’s disease, providing hope for better outcomes for those at high genetic risk.
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