Lisa Pisano, 54, had heart failure and end-stage kidney disease that required regular dialysis. However, she did not qualify for a traditional combined heart and kidney transplant because she had several chronic conditions that made her an unsuitable candidate. The supply of human organs is limited, so in order to be eligible for multiple transplants, a person must meet certain criteria that lead to the assumption that the results of the operation will be good.
L. Pisano’s doctors began to consider the possibility of fitting her with a mechanical artificial heart, which could extend the patient’s life. However, implanting an artificial heart would be very risky if the woman continues to receive dialysis – so she would still need to secure a functioning kidney. Complicating matters was the fact that due to the antibodies circulating in Pisano’s blood, she could have had to wait years for a human kidney to “match” her immune system.
But she didn’t have that much time. “She only had a few weeks to live,” said Dr. Robert Montgomery.
Since a human kidney was not available, the surgical team sought organs from genetically edited pigs instead.
In two procedures over nine days in early April, Pisano received an artificial heart, then a pig kidney and thymus gland. The latter helps train the body’s immune cells, so its inclusion should help prevent a woman’s immune system from rejecting the kidney, according to doctors.
“No human or pig kidney has ever been transplanted into an artificial heart patient, so we didn’t know if it would work,” Montgomery said. “We have innovatively combined two miracles of modern medicine.”
When the team pitched the idea to patients, “she was all for it from the beginning,” said Pisano’s husband, Todd.
It is also the first time that a pig’s thymus gland and kidney have been transplanted into a living person/ Earlier, New York University tried a similar procedure on a brain-dead organ donor. In addition to reprogramming Pisano’s immune system, the thymus is expected to allow her to take lower doses of immune-suppressing drugs than she would normally need. The thymus gland itself was inserted into the transplanted kidney.
The pig from which both organs were harvested had been genetically edited to lack a certain type of sugar in its tissues. This sugar, known as alpha-gal, triggers an immune response in humans that would have caused the organ to be rejected.
This type of genetically edited kidney is relatively simple — compared to the kind that was recently transplanted to a man in Massachusetts. In that case, the new kidney was obtained from a pig from which three pig genes had been removed and seven human genes had been added. Montgomery said that because of the differences in how each pig is raised, it is likely that these simpler kidneys could be put into widespread use more quickly.
Now, 12 days after the transplant, Pisano’s kidney function “is perfect and she has no signs of rejection,” says Dr. R. Montgomery. He added that the woman will need time to fully recover before being released to a rehabilitation facility.
Like Todd, Lisa hopes that more people will be able to benefit from this dual procedure in the future. “My goal was to make sure that I was made for someone else – that someone else would see what I went through and take the leap, take the risk,” said L. Pisano.
Let’s talk about „Live Science“.
“We have innovatively combined two wonders of modern medicine”
SEGA Announces Release of “KAGE~Shadow of The Ninja” on Nintendo Switch/PS5/PS4 in August 2024
SEGA announced that “KAGE~Shadow of The Ninja” developed by NatsumeAtari will be released on the Nintendo Switch / PS5 / PS4 platform on August 29, 2024 (Thursday), supporting Traditional Chinese and other languages .
[Tha na susbaint a leanas uile bho fhiosan naidheachd a thug an neach-dèanamh seachad]
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This time, SEGA and Natsume Atari have decided on a publishing deal for the boxed version of the new game, and they will be responsible for the production and sales of the game in Japan and Asia.
Ninja action game masterpiece returns after 34 years! The original version was a home console game software released in 1990. It was a very complete work among the action games launched for the red and white consoles at that time, in particular, players received a great reception for the two-player cooperative game mode. At that time, this work was translated as “Shadow of Ninja” in North America and “Blue Shadow” in Europe. Now it has finally been resurrected as an entirely new work.
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A classic two-player cooperative action game!
In addition to the single-player mode, the game can also be played in the original’s acclaimed two-player mode. Players can choose two characters, male and female, and work together to defeat powerful enemies.
Focus on revealing details and high quality bitmaps!
The previous game “The Mystery of the Black Cloak” was highly praised for its detailed 16-bit pixel graphics, and this game is certainly no exception, preserving the consistent detailed style. The bitmaps carefully created by the development team make the whole game more attractive.
The great composer “Iku Mizutani” who composed music from Natsume’s work participated in the production!
Mr. Iku Mizutani, who is responsible for Natsume style music of the original game, series “Shatterhand” and “Badge Fighter”, will also participate in the production of the game as a composer. The expert guitar solo is not to be missed!
Dynamic Production, who participated in the original production, will also be responsible for the pictures!
The main gameplay and character portraits of this game will be performed by Dynamic Production, which was responsible for the same content in the original work.
Since its establishment in 1969, Dynamic Production’s main business has been managing and overseeing the production of comic works created by cartoonists, novelists and original comic authors headed by Nagai Go. In addition, Dynamic Production is also responsible for event registration and copyright management of its authors.
Introduction to “Tachibana Future King”
He was born on May 11, 1976. He was born in Saitama Prefecture. He was once an assistant to Go Nagai and has published serial works such as “Invincible Iron Maiden” and “Invincible Iron Maiden” since his debut in 2004. To this day, he continues to publish short comics, original comics, drawings and other works regardless of genre.
PV 1 is now released
The first PV of the promotional video for this game is now available on the official website of “KAGE~Shadow of The Ninja”, please don’t miss it!
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SEGA Announces Release of “KAGE~Shadow of The Ninja” on Nintendo Switch/PS5/PS4 in August 2024
CRM and Neuromarketing help companies sell more
2024-04-25 20:16:18
Search State of Sales, carried out by Salesforce, revealed that selling has become more difficult. Sales professionals are adapting to an increasingly competitive world with limited resources. Success goes beyond simple business transactions; it’s about understanding the consumer’s mind and offering personalized, impactful experiences. In this context, Neuromarketing and sales automation through Customer Relationship Management (CRM) systems emerge as fundamental pillars for business growth. And exploring the power of mental triggers in the sales funnel and CRM automation can be the difference in this journey in search of closing more deals.
Attractive colors and images, an emotional call and a repetitive jingle in TV commercials are elements purposely designed with the aim of generating a connection between the brand and the public. This is the impact of Neuromarketing, a discipline that combines cognitive biases and mental triggers, and has revolutionized the way companies understand and influence consumer behavior.
According to the Brazilian Institute of Neuromarketing (IBN), cognitive biases are predictable patterns of thinking that arise due to cognitive limitations, past experiences and contextual influences, and can lead to irrational decisions. People tend to seek and interpret information in a way that confirms their pre-existing beliefs, for example. This is confirmation bias and can lead to a tendency to ignore contrary evidence or give more weight to information that confirms your opinions.
On the other hand, the IBN states that mental triggers are stimuli or signals that activate certain areas of the brain and trigger an emotional or behavioral response. They are designed to influence behavior and purchasing decisions subconsciously through words, images, colors, sounds or even scents that evoke specific emotional associations.
For neurocommunication and neurosales specialist, Mariana Provazi, understanding these biases allows marketers to create strategies that take advantage of these cognitive distortions to positively influence consumer behavior. “Mental triggers are a powerful tool for capturing consumers’ attention and creating emotional connections with brands. They allow us to effectively communicate the benefits of a product or service, through messages and campaigns that resonate deeply with target audiences and influence customers to act in desired ways,” she explains.
The Customer Relationship Management (CRM) model emerged 50 years ago, absorbing marketing concepts only in the 1980s and automation software in the following decades. For Mariana Provazi, today CRM is a crucial solution for companies that want to optimize their relationship with consumers and with the implementation of cognitive biases and mental triggers, this relationship has made decision-making even more efficient, generating a significant increase in sales. “CRM automation focused on the consumer journey and experience has allowed companies to personalize their interactions with customers based on behavioral data and purchase history, increasing the efficiency of strategies in the sales funnel”, highlights the expert.
At Humaniza Comunicação Integrada, of which Mariana Provazi is CEO, the implementation of CRM has already been carried out in more than 20 companies and in six months customers already have the system in full operation with positive results. “During the CRM implementation, we already configured the entire customer journey using Neuromarketing techniques, with cognitive biases and mental triggers, in marketing and sales strategies. And we observed that companies that use the tool with this configuration increased the conversion rate of leads into customers by 10 times, in addition to greater loyalty”, she explains.
Mariana reinforces that in an increasingly competitive business scenario, the intelligent combination of Neuromarketing and sales automation through CRM proves to be a winning strategy for boosting growth and customer loyalty. For the businesswoman, by understanding the power of mental triggers and applying them ethically and strategically, in addition to increasing their sales, companies can also create deeper and lasting connections with their customers. “The future of marketing and sales is driven by cognitive science and technological innovation”, adds Mariana Provazi.
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