The researchers found that vitamin D and omega-3 fatty acids of marine origin, also called fish oil, are not effective in reducing systemic inflammation. The study, published in the journal Clinical Chemistry, is an analysis of Vitamin D and Omega-3 TriaL (VITAL) performed by investigators from Brigham and Women's Hospital in the United Kingdom. .
"People generally think that these supplements can prevent inflammatory diseases, but when a patient asks his doctor," Should I take this supplement? "
"Doctors often do not know what to advise, since there have been no large-scale clinical trials." VITAL provides a large dataset to answer these questions, "said the author. author Karen Costenbader.
The VITAL study is a randomized, double-blind, placebo-controlled study in which researchers tested the effects of vitamin D supplements (2000 IU / day), omega-3 (1 g / day), or both.
For this analysis, they tested the levels of three known biomarkers of inflammation at the start of the test and after a year of taking supplements or a placebo.
The authors analyzed biomarkers for only one subgroup of the initial trial population – about 1,500 of the more than 25,000 participants.
It was interleukin-6 (IL-6), tumor necrosis factor-2 receptor, and high-sensitivity C-reactive protein (hsCRP).
The team found that no supplement reduced biomarkers to one year.
Surprisingly, among those taking the vitamin D supplement, instead of decreasing, IL-6 levels increased by 8.2%.
The researchers indicated that among participants whose fish consumption was low at the start of the trial, hsCRP levels decreased in those taking the omega-3 supplement.
"We find that people whose fish consumption was initially low had a reduction in one of the biomarkers of inflammation," Costenbader said.
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. (tagsToTranslate) Study of risk of inflammation (t) (t) Vitamin D