Within the framework of the XXXVIII Congress of the Madrid Association of Companion Animal Veterinarians (AMVAC), in a space dedicated to medicine and surgery of the reproduction and urinary system, Virbac has presented the essential drugs in canine and feline reproduction hand from several speakers of the highest level of veterinary medicine.
Xiomara lucas, veterinarian with a European specialization in animal reproduction and professor at the Faculty of Veterinary Medicine at the University of Murcia, as well as Josep Arús, Graduated from the European College for Animal Reproduction, have presented various topics in their talks, such as practical use of aglepristone in canine and feline reproduction, the importance of detecting prostate pathologies, waves applications and advantages of deslorelin in small animals.
Arús focused his presentation, entitled “The prostate also exists. Look for it and you will find it”, on explaining the importance of detecting prostate diseases. For this, the canine specific prostate esterase (CPSE) in serum, which is recognized as a valid biomarker and specific for canine prostate disorders, because its content is higher in the serum of dogs affected by different prostate disorders such as benign prostatic hyperplasia, bacterial prostatitis, and prostate cancer.
Thus, the study of CPSE in daily clinical practice has several objectives, such as the diagnosis of benign prostatic hyperplasia, or preventive screening for prostate disorders in healthy dogs.
In this sense, Speed ™ CPSE is a quantitative rapid test. of Virbac that allows the analysis of circulating CPSE by laser-induced fluorescence analysis.
CPSE AND PROSTATIC DISEASE
Arús insisted on his presentation at the need to consider and address potential prostate problems effectively, since many times it is not taken into account, and it is behind “recurrent urinary infections”, “fevers of unknown origin”, “even lameness and paresis”.
Therefore, perform general checks and use specific diagnostic methods to rule out prostate problems it becomes a necessity in many of these cases. Apart from diagnostic imaging methods, the expert spoke about laboratory techniques.
In this regard, Arús placed special emphasis on the ease and reliability of CPSE analysis circulating to detect alterations in the prostate, and that, according to the veterinarian “should be included in all geriatric profiles of non-neutered male dogs”.
MULTIPLE USES OF DESLORELIN
For his part, Xiomara Lucas highlighted the use of deslorelin, an alternative to surgical castration. There has been a while Suprelorin® from Virbac, whose active substance is deslorelin acetate, a subcutaneous implant for chemical castration in the dog. The vet applies it like a microchip: does not require surgery or anesthesia, just a puncture. The effect it causes on the dog is the same as castration. At 6 weeks after its administration (as would occur with surgical castration) the dog is completely infertile and the effect is maintained for a minimum of 6 months.
The product is presented in the form of a biocompatible implant that disintegrates over time (6-12 months), a small white cylinder similar in size to a microchip. It is registered to induce transient sterility in male dogs sexually mature, uncastrated and healthy.
Deslorelin implants act on the pituitary, blocking the entire cascade of sex hormones, both those that are produced in the sexual organs and those that are released in other organs. In the case of surgical sterilization, total blockage does not occur, and the production of other sex hormones, such as FSH and LH, is even increased.
In this sense, the expert highlighted the safety and efficacy of the product, although she comments “that the response varies according to the individual. It is highly variable in the canine species, and highly variable in the feline species., and this is one of the few contraindications that we can put to the product ”.
Likewise, after evaluating the effectiveness of the use of the drug to induce transient sterility, Lucas highlights “its use to produce delayed puberty as one of the most powerful avenues of investigation“, since it is an option “very interesting in shelters or shelters to control the population in these centers “, before the animal is put up for adoption and sterilized,” and thus avoid the expense of surgery“.
He also commented on his use as part of the treatment of hormone sensitive urinary incontinence, alopecia X syndrome, or its use on exotic animals, such as control of hyperadrenocorticism in male ferrets.
Regarding the use of deslorelin as an alternative to surgical sterilization, Lucas explains that, as a result of the recent published studies “where it is being observed that the surgical sterilization entails a series of future inconveniences on the health of the animal ”, a lot of research has been carried out and alternative methods to surgery have emerged, such as deslorelin.
After reviewing the numerous studies that suggest various side effects associated with surgical sterilization, how can be osteoarticular problems, predisposition to certain tumors, or learning disabilities, Lucas believes that we should deepen the use of drugs such as deslorelina, since, in relation to surgical sterilization “although it has been a procedure that we have always done, currently we know that it is not safe for the animal”.
ALIZIN THERAPEUTIC OPTIONS
Regarding the use of aglepristone (Alizin), the veterinarian spoke of its efficacy in the medical treatment of pyometers, mucometers and hydrometers, as a stabilizing agent prior to surgical treatment, or as method of termination of pregnancy, since, according to Lucas, “It is the best abortifacient we know”.
Likewise, the expert commented in her presentation on the potential uses as a method of induction of labor and caesarean section programming, since it is effective in “those animals with a very high dystocic risk, where we do not want to perform the cesarean section at dawn, with an animal with signs of labor and fetal distress”.
On the other hand, in the talk they stood out other uses of Alizin, As the control of the systemic effects of progesterone, “Like diabetes mellitus or acromegaly”, or its use in the therapy of certain neoplastic processes. “In the case of breast tumors and prior to surgery, even if it is in the experimentation phase, has been shown to significantly reduce the rate of tumor proliferation in those with progesterone receptors”
On feline species, apart from the interruption of pregnancy, or pyometry treatment, Lucas highlights its effectiveness in the treatment of mammary fibroadenomatosis, which he defines as “king of Alizin treatment on cats”. Abortive use was also discussed in other species, such as rabbits or rats.
The talks will be available until February 2022 for anyone who could not attend live.