The immune response to SARS-CoV-2 decreases in the three months after infection and depends on the severity of the disease, suggests an article published today in “Nature Microbiology.” The study, which provides information on the body’s response to the virus, may have important implications for vaccine design and disease management.
Although people infected with SARS-CoV-2 generate an immune response to the virus, the duration of the response is uncertain and it is not clear how long people will be protected. Katie Doores’ team at King’s College London, (United Kingdom) analyzed the antibody response of 59 patients and 37 healthcare workers at Guy’s and St Thomas’ NHS Foundation Trust in London over three months after the onset of your symptoms.
As it happens in acute viral infections, the antibody response peaked about a month after the onset of symptoms, before beginning to decline.
People with severe disease generated the strongest antibody response, and although it decreased, neutralizing antibodies were still detectable more than 60 days after symptoms began.