Covid-19: in several countries of the world, masks are falling – FRANCE 24

  1. Covid-19: in several countries of the world, masks are fallingFRANCE 24
  2. Covid-19: in Israel, the mask is no longer mandatory indoorsFranceinfo
  3. Farewell masks, hello handshakes: Israel comes out of COVID and inspiresThe Times of Israël
  4. Israel: end of the obligation to wear a mask in closed public placesSouth West
  5. Israel: Lifting Of The Obligation To Wear A Mask In Enclosed Spacesi24NEWS in French
  6. See full coverage on Google News

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Vaccination against HIV is not in sight

One person infected with HIV dies every minute worldwide. The UN wants to end the AIDS epidemic by 2030. But: A vaccination is not in sight. Why can’t AIDS be stopped by vaccination until today?

Forty years ago – in early June 1981 – the American Disease Control Agency (CDC) reported a mysterious new disease for the first time. Five homosexual men had a particular form of pneumonia.

40 years later, of the 77 million people infected with HIV worldwide to date, 35 million have died. Why does HIV not what at Coronavirus developed within a few months: The spread by a vaccination to stop?

The HI virus works differently than Corona

“This has to do with the nature of the HI virus, among other things,” explains Dr. Joachim Hauber from the Leibniz Institute for Experimental Virology in Hamburg in conversation with t-online. HIV is a retrovirus that works like this: After the infection The genetic material of the virus, the virus RNA, penetrates the human cell.

Hauber: “By a enzyme the virus turns this RNA into DNA translated, which is irreversibly incorporated into human DNA. In the process of translation into the human genome, many copying errors occur, that is, the virus mutates very quickly. “For a vaccination, this means: It would work well against the original virus, but it quickly loses its effectiveness against virus mutants.

The HI virus is also particularly treacherous because it can lie dormant in the human body for a long time and only then shows its fatal effect. Since the virus RNA gets into the human DNA, there is then a blueprint for the virus to multiply.

“If the blueprint stored in the cell nucleus is activated immediately or later, countless progeny viruses are formed, which in turn infect other cells in the human organism,” explains Hauber. “This is a specific group of T lymphocytes, important immune defense cells in the body. These cells are due to the Virus infection impaired in their function and ultimately die. The immune system as a result, can no longer do its work properly. The result is secondary infections with other viruses or bacteria, which can be fatal. “

Good medication, but no cure so far

For the treatment of HIV infections, so-called antiretroviral drugs exist that are very effective and can suppress the viral load so much that it can no longer be detected. Hauber: “However, these drugs cannot remove HIV from the affected cells. The patients therefore have to take their antiviral medicine every day and for life, but are usually no longer infectious. If the drugs are well tolerated, the people treated accordingly have one almost the same life expectancy as non-infected people. “

The UN have now announced that as a goal Aids– End the epidemic by 2030. How can something succeed in nine years that was not possible in the previous 40 years? New drugs give hope.

Gene therapy as a future expectation

Gene therapy holds great promise for curing HIV patients. So-called designer enzymes, such as the CRISPR / Cas9 system, have become known. The French geneticist Emmanuelle Charpentier and the US biochemist Jennifer Doudna were awarded the Nobel Prize in Chemistry in 2020 for the discovery of this process.

Hauber explains the method, which is also known as gene scissors: “To do this, for example, one would take blood from the patient T cells isolate and introduce a corresponding designer enzyme gene. The treated cells are then returned to the body. After the introduction of the appropriate Gene The designer enzymes are produced by the cells in the cells of HIV patients, track down the virus genome and inactivate or remove the virus DNA and thus HIV. “

In conjunction, for example, with HIV-specific antibody genes, this approach could lead to a cure. The disadvantage: “However, this very complex therapy is largely developed in the first world and is also used there first.”

AIDS remains a problem for the poor

But: AIDS remains a problem, especially in poorer countries. According to the latest figures (2019), 95 percent of those infected with HIV live in developing countries. Southern Africa is particularly affected, with disease rates of up to 40 percent in some countries. For comparison: In Germany there are only about 90,000 infected people – a rate of 0.1 percent.

In addition to prevention (such as education and the distribution of protective condoms), it would be important to be able to make effective therapies possible in these countries as well.

Hauber’s approach: “To treat as many HIV-infected patients as possible in developing countries, for example, a gene therapy that can be administered directly could be an option.” This would require gene ferries, i.e. the vectors known from the corona vaccines that transport the gene scissors enzymes or antibodies into the body. “These therapies could then be administered around the world, including in developing countries, relatively easily by direct injection into the patient’s organism.”

The “UNAIDS program” of the United Nations calls for spending on prevention programs, tests and treatments to be increased from less than 20 billion dollars in the year to 2025 to at least 29 billion dollars (almost 24 billion euros) per year.

Important NOTE: The information is in no way a substitute for professional advice or treatment by trained and recognized doctors. The contents of t-online cannot and must not be used to independently make diagnoses or start treatments.

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Corona incidence in summer 2021 will soon be slowed down

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Coronavirus variants create ‘super cells’ to replicate

The coronavirus deploys treasures of inventiveness to escape attacks from the immune system. In a pre-publication, researchers describe its ability to fuse cells to replicate without antibodies.

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During infection, viruses attach themselves to a host cell, enter it and chain their genetic material and their structural proteins. Once the virions are assembled, they leave the cell to infect another. This very simplified diagram is valid for many viruses whose SARS-CoV-2. Outside the cell, virions are at the mercy of the immune system, including neutralizing antibodies that capture them before they infect another cell.

As viruses and humans have evolved together for millennia, microscopic entities have developed escape strategies. There is obviously the ability of viruses to mutate which, by accumulating changes in their structure, are no longer recognized by antibodies. Thus several variants of the coronavirus, with a resistance increased neutralizing antibodies, have emerged. But this is not the only strategy available to them.

Some viruses are capable of infecting new cells without being released into the extracellular medium, and therefore being vulnerable to antibodies; it is cell-to-cell propagation. There are several strategies, such as that of synapse viral practiced by the VIH or the virusherpes, or the passage via the junctions that hold the cells together. The coronavirus is also adept at cell-to-cell propagation, in particular the technique of fusion cellular. Cells infected with SARS-CoV-2 can fuse with their neighbors, forming a virion supercell or superfactory. This phenomenon has been described in experiments in vitro carried out by an international team of researchers, and the results of which are only available pre-publication nowadays.

Merge cells to infect them in the absence of immunity

These super cells are called syncitia – or syncitium in the singular. They are larger than normal cells and contain several nuclei, one for each cell fused during a viral infection. To observe the formation of syncitia caused by the coronavirus, the scientists used a cell line of lung, whose nucleus is labeled, which expresses the ACE2 coronavirus receptor. These healthy cells are artificially infected by the addition of a single cell infected with SARS-CoV-2. At 36 hours post-infection, 20% of the nuclei of the cells are included in a syncitium, arranged in a ring. Thanks to a time-lapse, scientists were able to observe the appearance of the first syncitia as early as 6 hours after infection.

Is this mode of transmission sensitive to neutralizing antibodies formed after vaccination ? According to the results of scientists, no. Scientists tested the effect of an antibody monoclonal and plasmas from convalescent patients on this mode of propagation. Alpha variants (B.1.1.7) and Beta (B.1.351) are well sensitive to neutralizing antibodies, with less efficacy for the Beta variant as had been observed since its emergence. But neutralizing antibodies do not prevent the variants to spread from cell to cell via the syncitia.

Vaccines questioned?

Fortunately, this does not mean that the vaccines are good to throw away and lose their effectiveness. Cell-to-cell spread, if observed in vitro and probably exists in vivo, especially in the lungs, may not be the primary route for the virus to spread through the body. In addition, vaccination triggers the production of neutralizing antibodies, but also lymphocytes who know how to identify and destroy infected cells, and therefore syncitia. On the other hand, the authors of the study suggest that syncitia may be involved in the persistence of the infection, especially in immunocompromised people where it remains active for several months.

Interested in what you just read?

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How do you do it.. How to detect and remove any virus from your iPhone

If you’re afraid of viruses on your iPhone, malware can’t do much, even if it finds its way into your phone, thanks to the way Apple designed the operating system. iOSHowever, usually, look for behavior such as redirect Safari It sends itself to web pages you didn’t request, emails and text messages are automatically sent without your permission, or the App Store opens on its own.

According to the website,business insider‘No matter what symptoms you’re experiencing, the first thing you should try to determine is if the problem you’re experiencing occurs all the time, or only when you’re running a specific app, write down the problem and watch the app you’re using when it happens.

If you can narrow down the issue to a single app, see if there is an update available for it in the App Store, that might fix the problem, but if not, uninstall that app.

If the problem disappears after uninstalling the app, now you know the root cause, you can try to reinstall the app again to see if the issue is resolved, or contact the technical support of the app maker.

And if you can’t limit the problem to one app, your next step should be to restart your iPhone, just like restarting your computer, turning your phone off and back on again can solve a lot of unexpected issues.

Clear Cache in Safari

Some problems, especially those related to web browsing, can be resolved by clearing your browser cache, and this is especially true if you find that Safari It redirects to websites you didn’t request or links stop working the way they should.

Restore your phone to a previous backup

If none of these things solve your problem, it may require more severe actions to try to get your phone back to its best shape. If you have a good idea of ​​when your phone started experiencing problems, you may be able to restore your phone to a backup from before the infection.

But this will erase everything added to your phone since that backup, including apps, photos, and music, so only do this if you’re sure you have a serious problem and nothing else has worked.

Start over with factory settings

If resetting your phone to an old backup didn’t fix the problem, and you’re still affected by malware or another glitch, you have one last method to try.

Reset your iPhone to factory settings, and instead of restoring a backup, set up the phone as a new device, and don’t restore any apps or data.

Work with the phone in its new factory condition, if the problem goes away, start downloading the apps you lost manually.

If the problem persists even after resetting the phone, then what you have is a hardware issue, and no virus can live on the iPhone through factory reset, so you should take the phone to the Apple Store for service.

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Monkey pox virus has been detected in the UK

There have been two cases of the monkey pox virus in Great Britain. One person is treated in isolation in the hospital.

the essentials in brief

  • There have been cases of monkey pox in the UK.
  • It affects two people from the same household in Wales.

In the middle of the corona crisis, Great Britain is apparently already struggling with the next virus: monkey pox has been detected. The British Minister of Health Matt Hancock confirmed such cases on Thursday, reported the “Mirror”.

These are said to be two Welsh people who were infected with the virus. The two are from the same household. One person is currently being treated in isolation in the hospital.

Richard Firth from the Welsh health authority urges calm. He says the risk to the general public is very low. “Broad measures have been taken to reduce the possibility of further infection.”


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Argentines use it every day to work and now it is a danger: it steals the cards

In the last days, four new security vulnerabilities were identified that affect all the products of the Microsoft Office suite, including Excel and Office online.

The news was released by the threat intelligence division of Check Point Research (CRP), a cybersecurity and software development company.

These threats are “hidden” in Office files that arrive via email. This technique is known as “phishing“and, according to an annual Avast report, 28% of Argentines received a phishing campaign and the 15% confirmed having fallen for the scam.

What is phishing? It is a digital scam that sends messages with malicious links and seeks to induce the user to download a virus that controls devices and steals information.

For Microsoft Office files, the email with the attachment may come from a known sender who did not know it was a malicious file, or it may be a message with a subject that “surprises” users and forces them to open the file.

When users download Excel or Word document, the vulnerability is unleashed in the system.

How is it about vulnerabilities that are ingrained in legacy code (that is, “live” in code that is no longer directly supported by Microsoft), have the ability to run code on the computer through the infected Office documents.

Therefore, criminals can introduce into the system un remote access tool (also known by its acronym rat), a keylogger or ransomware to steal bank accounts.

What is each one and why is it dangerous?

First, a “rat” is a remote access trojan which opens a back door in a system to gain full control of the computer. They go completely unnoticed and enter an email attachment or video game.

In the case of a keylogger, is about software that “reads” keyboard letters that people pulse. Therefore, cybercriminals can obtain passwords and steal bank accounts.

Basically what they do is collect everything we write on our devices to later carry out their attacks. They are capable of registering therefore the credentials that we write, as well as the passwords.

Lastly, a ransomware it’s a malware que access information and files on a computer. The encrypts and does not allow access to them. Once it has entered the system, it threatens to publish the information in exchange for a sum of money.

Months ago, the Cencosud company was attacked with ransomware in Argentina and wreaked havoc on its operations.

How to protect yourself, according to experts

Según Check Point, Word and Excel documents are hidden behind a “.EXE”, an executable file format. Therefore, users should double check the “.doc” format before clicking.

In addition, experts recommend update Microsoft software and do not use previous versions: “I strongly urge Windows users to update your software immediately, as there are numerous possible attack vectors by an attacker activating the vulnerabilities we find“reported Yaniv Balmas, director of cyber research at Check Point.

On the other hand, it is important have an antivirus, although there are those who sometimes see it as a superfluous expense.

Antivirus software is capable of detecting different types of malware such as Trojans, ransomware, worms, spyware and viruses to prevent their entry to the computer.

How to update Microsoft Office in a few steps

  • First of all, go to beginning. Then, select the option “Setting“.

  • Login to Update and security and click “Windows Update”.

  • To check for updates manually, “Look for updates“The next step is to select” advanced options “and choose the automatic installation of updates.

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what are monoclonal antibodies

It is one of the few treatments that can be used against Covid-19. Monoclonal antibodies will be able to be used to treat more patients from June 11. The National Medicines Safety Agency (ANSM) released a press release on Tuesday, June 8 to extend access to two dual monoclonal antibody therapies to new audiences.

In practice, children aged 12 and over, at high risk of developing a severe form of Covid-19, adult patients with chronic pathology (obesity, diabetes, kidney failure) or being infected with HIV are concerned.

This type of treatment was talked about in October, when Donald Trump, then President of the United States, was infected with Covid-19. He had then received an experimental cocktail of treatments comprising monoclonal antibodies.

A product that minimizes the effects of Covid-19

Monoclonal antibodies are naturally produced by the body, but they can be produced in the laboratory. Normally, they take several days to be made by the human body, but the idea of ​​treatment is to inject them earlier, as much as possible. 5 days after onset of symptoms. Their role is then to paralyze the virus to prevent it from infecting cells.

The treatment could therefore limit the so-called “inflammatory” phase of Covid-19: he would not avoid it, but would minimize its effects.

For the time being, the use of this treatment is still very limited, sinceit does not yet have a marketing authorization. A rolling review procedure is also underway at the European Medicines Agency, with a view to possible authorization.

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global pandemic update

published on Wednesday 09 June 2021 at 13:18

New measures, new reports and highlights: an update on the latest developments in the Covid-19 pandemic around the world.

– Green light from the European Parliament for the Covid certificate –

MEPs gave their final green light on Wednesday to the European Covid digital certificate, intended to facilitate travel this summer within the EU, it is now up to the States to put it in place by July 1.

These certificates prove that a person has been vaccinated against Covid-19, that they have tested negative or that they are immune after an infection. They are issued free of charge, in digital or paper format, and must make it possible to avoid making quarantines in the countries of destination.

– France and Belgium loosen the grip –

A new pan of social life resumed Wednesday for the French after seven months of deprivation due to the epidemic, with the reopening of swimming pools, gyms, bars and restaurants without terrace, and the extension of the curfew from 9:00 p.m. to 11:00 p.m. Teleworking is relaxed, as are the rules in canteens.

– Spain relaxes the conditions for entering its territory –

A decree published in the Official Journal on Wednesday states that, as with travelers arriving by plane, Spain will now allow travelers arriving by road if they have a vaccination certificate. Until now, the country required a negative PCR test of less than 72 hours for anyone wishing to cross the French land border to travel to Spain.

The Spanish authorities also raised Wednesday to 12 years, against 6 years so far, the minimum age from which a negative test for Covid-19 is necessary to enter Spain.

– Vietnam for a postponement of the Southeast Asian Games –

Vietnam plans to postpone to July 2022 the 31st Southeast Asian Games (SEAGames) which are to be held from November 21 to December 2, 2021 on its soil, state media said on Wednesday, as the country is grappling with a new wave of Covid-19 cases.

The 31st Southeast Asian Games are expected to attract nearly 20,000 participants, including around 7,000 athletes, from 11 countries in the region, according to official media.

– More than 3.75 million dead –

The pandemic has killed more than 3.75 million people worldwide since the end of December 2019, according to a report established by AFP from official sources on Wednesday at 10:00 GMT.

After the United States (598,326 dead), the countries with the highest number of deaths are Brazil (476,792), India (353,528), Mexico (229,100) and Peru (187,157).

Among the countries hardest hit, Peru is the one that deplores the highest number of deaths in relation to its population.

These figures, which are based on daily reports from national health authorities, are generally underestimated. They exclude the upward revisions carried out a posteriori by certain statistical organizations.

The WHO even estimates, taking into account the excess mortality directly and indirectly linked to Covid-19, that the results of the pandemic could be two to three times higher than that officially recorded.

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“The only hypothesis that makes sense”, says the US super-detective – Il Tempo

A theory that takes shape more and more despite the silence in Beijing. It is the one about the origin of the virus that shocked the world, Covid-19, and the hypothesis of an “escape” from a Chinese laboratory in Wuhan, now considered “plausible” to the point of deserving “further investigations”. And for those who have investigated the birth of the virus it is the only hypothesis that makes sense.

It was already running in 2019. No comment.  The virologist mute on suspected cases a year before the pandemic

This is the conclusion reached by a US national laboratory on the origins of the corovavirus, according to the ‘Wall Street Journal’, citing people familiar with the document. The study was carried out in May 2020 by the ‘Lawrence Livermore National Laboratory’ in California and was the subject of analysis by the State Department – the newspaper writes – when it conducted an investigation into the origins of the pandemic during the last months of the Trump administration. . The Californian laboratory’s assessment was based on genome analysis of the Covid-19 virus, reports the WSJ, and was only disclosed now that US President Joe Biden has publicly ordered an investigation into the matter.

Biological weapons in the Wuhan laboratory ?.  The virologist Crisanti and the mystery of Covid in China

“China has had a problematic attitude from the beginning. The Beijing authorities have just announced that they will refuse any future cooperation. One wonders why China is behaving so suspiciously, if it has nothing to hide. The escape from a laboratory. is not 100% certain but, at this point, it is the only hypothesis that makes sense and is consistent with the information in our possession “, said David Asher, from September 2020 to January 2021 at the head of the investigation of the Department of the US State on the origins of Covid-19, in an interview published by ‘Repubblica’, while the hypothesis of an accidental origin of the Covid-19 pandemic seems to be advanced.

In September 80% of Italians vaccinated.  And we are already thinking about the third dose

“Our investigation had allowed us to discover that at the beginning of November 2019 several employees of the Wuhan Institute of Virology had fallen ill with symptoms similar to that of the flu or Covid. It is likely that, starting in October , all have been infected by Covid-19. Since then, many researchers from the Institute of Virology have disappeared: perhaps they died, or perhaps they made them disappear, “Asher explained, according to which” the Chinese authorities have tried to control a laboratory accident occurred in October 2019, perhaps earlier, and they did not succeed “.

Asher stressed that “from January 22 or 23, the Chinese People’s Army took charge of the Wuhan case. The person chosen to coordinate the operations is Major General Chen Wei, specialist in biological weapons” and this it would show that the Wuhan Institute “had links to Chinese military research”. Finally, according to Asher, “the Chinese people have no responsibility, but Xi Jinping and his acolytes do. I believe it is also necessary to impose sanctions on China and implement a much stricter international control over virological research”.

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