Pfizer vaccine: no cardiovascular risk identified in people over 75

This is good news that is valid after the first injection as well as the second injection. The results of an official French study made public on Monday “reassuringly suggest that vaccination” against Covid-19 with Pfizer / BioNTech “does not appear to be associated with an increased risk of serious cardiovascular events in people aged 75 and over.”

In more detail, the researchers took into account all the cases of hospitalization reported in France for heart attacks, strokes and pulmonary embolisms between December 2020 and March 2021 in people aged 75 and over, vaccinated and unvaccinated (i.e. nearly 30,000 people). They compared the occurrence of these cardiovascular problems at different times: the periods of 14 days after the first and second doses of the vaccine were considered as risk periods, and all the others as control periods.

“Overall, the frequency of occurrence of cases of hospitalization for myocardial infarction, ischemic stroke, hemorrhagic stroke or pulmonary embolism in people aged 75 years and over did not differ significantly” between these different periods, concludes the study.

Epi-Phare researchers now plan to update these data: “Once the information is available, analyzes will be continued to measure these risks, particularly in people with a history of cardiovascular events, in younger populations, and also for other anti-Covid-19 vaccines”.

In May, in a previous study focusing on the Pfizer / BioNTech vaccine, the Epi-Phare group had established that vaccination reduced the risk of severe forms of Covid-19 by 87% in those over 75 as early as seven days after the second dose.

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Cancer patients should be satisfied with two doses of the vaccine

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Jerusalem: On Sunday, Israel retracted part of its policy regarding the third dose of the coronavirus vaccine, saying that unlike the latest announcement, cancer patients should settle for only two doses.

On Monday, Israel began giving a third dose of the Pfizer/Biontech vaccine to patients with weakened immune systems, including people who have had heart, lung and kidney transplants and some cancer patients.

But the Ministry of Health said on Sunday that after reviewing the data of hundreds of patients in oncology departments, the “recommendation at this stage is not to vaccinate” cancer patients.

“About 90 percent of patients receiving chemotherapy developed antibodies after two doses, and the level of antibodies remained high months after vaccination,” she added in an “clarification” to health funds and hospitals that provide doses.

“In addition, vaccination may have side effects … that may affect the treatment of diseases caused by tumors,” she added.

third dose

The Pfizer and Piontech groups said they would seek permission from US and European authorities to provide a third dose of the vaccine they had developed, but the European regulator says it is too early to know if a third dose is necessary.

The World Health Organization has expressed concern that a booster dose of the vaccine may come at the expense of countries whose citizens have not yet received the first two doses.

Israel was one of the fastest countries to launch a vaccination campaign with the Pfizer/Biontech vaccine, and this helped reduce the number of daily infections last month.

I decided to proceed with a third dose in light of the evidence “that patients with immunosuppression do not develop an adequate antibody response after two doses” and after the number of daily infections began to rise again.

A spokesman for Sheba Medical Center, Israel’s largest hospital, told AFP that “dozens” of cancer patients had received a third dose since Monday.

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France recognizes Covishield vaccine, relief for Indians and many Africans

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France has just recognized the Covishield vaccine in its “health pass”, a relief, because this serum, which is a copy of the AstraZeneca vaccine produced in India, is used in many countries. Travel in France is therefore easier for Indians and many Africans vaccinated, especially as the quarantine rules are lightened for vaccinated people.

Two weeks after many of its European neighbors, France finally recognizes that Covishield is the equivalent of the AstraZeneca vaccine used in Europe, reports our correspondent in New Delhi, Sebastien Farcis. And that people who have received this serum will be able to benefit from the same rights of access to public places as those who have been vaccinated in France, with Moderna or Pfizer, among others.

This mainly concerns Indian residents, as well as those of the DRC or Nigeria, countries where Covishield is widely used. These vaccinated travelers will also no longer need to take a test on departure or arrival in France, or to go into quarantine.

This recognition of Covishield, India’s flagship vaccine, represents a symbolic success for New Delhi, which has lobbied all European countries to obtain it. Covishield is now approved by more than half of EU capitals, even before the European Medicines Agency can comment.

Read also : Covid-19: France introduces new border protection measures

Until then, Paris seemed hesitant. The vaccine is in fact not recognized at European level. Yet the WHO, the World Health Organization, gave it the green light. The Chinese Sinopharm and Sinovac vaccines are also validated by the WHO, but they still do not open the doors to French territory. The Russian Sputnik V either, but the latter is not recognized by either the WHO or the European Union.

This news comes at the right time to relaunch vaccination …

Dr Richard Mihigo, Africa Vaccination Coordinator for the World Health Organization

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A complex study determined that the Sputnik V and Sinopharm vaccines generate high cellular immunity

The studies that are being carried out on the high immunity generated by the Spuntik V and Sinopharm vaccines yielded satisfactory results in more than 80% of the cases analyzed by a team led by CONICET scientists.

This is a study to determine the so-called “cellular immunity”, different from those carried out on the presence of antibodies and their permanence in the system depending on the different vaccines that are applied in the country.

In general terms, it is about measuring the activation of T lymphocytes in people who were vaccinated with the Russian and Chinese drugs. And the first ones turned out were really very good.

Something had advanced the Buenos Aires Minister of Health, Daniel Gollan, when he recounted having had a meeting “with the Minister of Science, Technology and Innovation of the Nation, Roberto Salvarezza, where a first analysis of the effect of the disease and the vaccines was made. We noticed an excellent response in the activation of T lymphocytes to the Sputnik and Sinopharm vaccines. “

During that meeting, it was stated that “the great response to the T lymphocyte implies that in this line is what will last as a defense over time” and added that “there are those memory lymphocytes that register the coronavirus and keep it in memory” . “When they come into contact with that virus again, they quickly generate antibodies and ‘killer’ cells that kill the virus,” he explained.

The newspaper La Nación today publishes the results of these studies, according to which more than 90% of the people who received the two doses of the Sputnik V vaccine had cellular immunity, while those who were inoculated with a dose of Sinopharm more than 80% recorded response.

The complex platform on which the studies are carried out is proposed, at least for the moment, as a tool for public health decision-making and not so much as a study that can be accessed in a particular way. Although the idea is, at some point, to achieve the development that allows it.

The work allowed to determine that five of the six markers taken into account react consistently, while when the analysis is done in people who were not vaccinated or did not contract the virus, the T lymphocytes do not react.

Jorge Geffner, Professor of Immunology at the Faculty of Medicine of the University of Buenos Aires (UBA) and researcher at CONICET, explained to La Nación that “the immune system consists of two branches: innate immunity and adaptive immunity. The first integrates a great diversity of cell types. The second, only to two cell types: B and T lymphocytes. B lymphocytes they will be responsible for producing antibodies. T lymphocytes may acquire different functionalities and mediate different responses. They will destroy cells infected by the virus or release mediators called cytokines, in order to instruct the way in which cells of innate immunity will face the infection.

Both vaccination and infection generate the reaction of innate and adaptive immunity, for example with B lymphocytes producing antibodies, while the reaction of T lymphocytes generate other responses capable of destroying infected cells, among other reactions.

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“Maybe we’re at the peak of the fourth wave in Lisbon,” says Marta Temido. Seven more deaths and 3547 new cases of covid-19 in Portugal – PÚBLICO

“Maybe we’re at the peak of the fourth wave in Lisbon,” says Marta Temido. Seven more deaths and 3547 new covid-19 cases in PortugalPUBLICSee full coverage on Google News .

The first batch of Sputnik V vaccines produced in Argentina was approved and they will begin to distribute them

The Gamaleya National Research Center for Epidemiology and Microbiology, of the Russian Federation, approved today the first 140,625 doses of component 1 of the Sputnik V vaccine that were produced in Argentina by Richmond Laboratories. This was reported this afternoon to President Alberto Fernández by the CEO of that pharmaceutical company, Marcelo Figueiras.

“A few moments ago the Gamaleya Institute gave us approval of the first industrial batch manufactured by Laboratorios Richmond to be used in our country,” said Figueiras in a videoconference with Fernández.

As detailed, it is a first batch of 140,625 doses of component 1 of the vaccine, while the laboratory has already produced approximately 1.3 million doses of component 1 and 1,010,000 doses of component 2 that will be authorized in the following days.

The president thanked him “from the heart on behalf of all Argentines” and assured that it is “an infinite advance because it is very important that in a time like the one the world lives in Argentina we are producing a vaccine of the quality of the Sputnik V “.

“It fills us with pride. And beyond what we can help from the State, the merit is yours, that you invested so that Argentina is in a position to produce what it is producing and to supply the vaccines that we need so much. It is a huge pride that an Argentine laboratory has the technological capacity to develop a product as careful and as special as a vaccine of the nature of the vaccine against COVID-19 ”, he highlighted.

In addition, the President remarked that it is “a very important step and a private company has done it, the State has helped in what was within its reach, but the central merit is of private activity, which bet on technology, which put all the technology needed to produce this ”.

The President also pointed out that today is “a sad day because we have unfortunately passed the number of 100,000 deceased” and considered that “the best tribute we can pay them is to take care of those who are there and one way is to be able to continue making the vaccine in Argentina ”.

For his part, Figueiras also said he was proud of the achievement and conveyed his gratitude “to all those who collaborated with this process to be able to meet this challenge in such a short time, to the Presidency, to the Ministries of Health, of Economy and Productive Development, and to ANMAT, which supported and guided us, to our colleagues in the pharmaceutical industry, especially MR Pharma, and to so many companies from Argentina and abroad that have helped us, and especially our scientists, doctors , technicians, professionals who gave everything and will continue to give it ”.

“We are proud to add our humble contribution,” he said, noting: “We are with you to try to make a better country, count on us, we know we can count on you.”

The vaccines produced by Richmond are made with the antigen that is imported by Argentina from Russia. Formulation, filtering and packaging are carried out locally in order to strengthen the Strategic Vaccination Plan.

To date, Argentina has received 31,255,730 doses, of which 11,868,830 correspond to Sputnik V, (9,375,670 for component 1 and 2,493,160 for component 2); 9,072,000 to Sinopharm; 580,000 to AstraZeneca-Covishield, 1,944,000 to AstraZeneca through the WHO COVAX mechanism, and 7,790,900 to AstraZeneca and Oxford whose active ingredient was produced locally.

From the technology transfer of the Gamaleya Institute, it was possible for Argentina to produce vaccines against COVID-19 -with proven efficacy and safety- for the Argentine population and with a regional perspective, which positions the country as a key actor in the development of vaccines in the world.

Thus, from the beginning, the national State accompanied the efforts to finalize these agreements between public and private, enabling the Richmond Laboratory to carry out the technology transmission process and that the Sputnik V vaccine is currently produced from the antigen prepared in the plant located in Russia.

This stage called fill and finish consists of the final filling and conditioning of the vaccine, a production stage conducted in segregated facilities dedicated exclusively to the production of components 1 and 2 of the Sputnik V vaccine.

Likewise, the ANMAT will supervise and verify by means of the release of the elaborated batches so that they comply with the entire quality control process necessary for the care of the population.

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Vaccination of children: the UN warns of a risk of “absolute catastrophe”

RELIEF – For the UN, the situation is catastrophic. In many countries, the fight against Covid-19 has completely erased the fight against serious childhood illnesses, running the risk of new epidemics. Like the WHO, she insists on the importance of vaccination against diphtheria, tetanus and pertussis in particular.

As many countries focus on vaccination against Covid-19, immunization against other diseases is declining. This Thursday, the UN warns of a risk of “absolute disaster” if the dangerous delay in the vaccination of children due to the pandemic is not made up for.

In 2020, 23 million children fell through the cracks and did not receive all three doses of the diphtheria, tetanus and pertussis vaccine or DTP3, which serves as a baseline measure, according to published figures. Thursday by WHO and Unicef. This is the highest number since 2009 and it affects 3.7 million more children than in 2019. Even more serious in the eyes of the two agencies, 17 million children – most of whom live in either areas. conflict, remote places or slums deprived of health infrastructure – arguably had no dose in the last year.

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Covid-19: the challenge of vaccination

The consequences will be paid in death and loss of quality of life for the most vulnerable.– Henrietta Fore, director of Unicef

This numbers “are a clear alarm signal, the Covid-19 pandemic and the disruptions it has caused have caused us to lose precious ground that we cannot afford to give up and the consequences will be paid in death and loss of life. quality of life of the most vulnerable “, insisted the director of Unicef ​​Henrietta Fore, recalling that the “pandemic has further degraded a situation which was already bad”.

The DTP3 vaccination rate remained stuck at 86% for several years before the pandemic and in 2020 it fell to just 83%. In the case of measles, a highly contagious disease requiring a vaccination coverage rate of 95% to be well controlled, only 71% of children received the second dose.

Resources and personnel diverted and health restrictions lifted too quickly

The pandemic has forced resources and personnel to be diverted to the fight against Covid and many healthcare services have had to close or reduce their hours. People were also reluctant to move for fear of contamination, when containment measures did not prohibit them.

Unprotected children and too rapid lifting of health restrictions against Covid – which also partially protected against certain childhood diseases – are already having their effects, with for example measles rashes in Pakistan, underlined Dr. Kate O’Brien , Director of the Immunization Department at the World Health Organization in Geneva. These two factors combined are “the absolute catastrophe we are sounding the alarm against now because we need to act now to protect these children”, she hammered.

India, Pakistan and the Philippines very affected by the delay in vaccination

Southeast Asia was badly affected by the disruption caused by the pandemic, and DPT3 coverage rate fell from 91% to 85% in 2020 in India, which had the highest number of under-immunized children or not vaccinated at all last year: 3.5 million. Pakistan, Indonesia and the Philippines have also seen the number of unprotected children increase.

The Americas region, for its part, has “worrying long-term trend” although the decline linked to the pandemic has been modest (2 percentage points less than in 2019). “Fueled by lack of funding, misinformation about vaccines, instability and other factors form a worrying picture” in the region where “the vaccination rate continues to fall”, note the two agencies. Only 82% of children are fully immunized with the DTP vaccine, while this coverage rate was still 91% in 2016.

Mexico is among the countries where the number of children not covered by a first dose of DTP has increased the fastest, from 348,000 in 2019 to 454,000 last year. The Eastern Mediterranean region, which had seen the most spectacular fall in terms of immunization, was able to catch up with part of the ground.

Read also

  • Can BCG Tuberculosis Vaccine Help Fight Coronavirus?
  • Covid-19: G7 countries will distribute one billion doses of vaccines to poor countries

The UN stresses that it is important that the distribution of anti-Covid vaccines does not come at the expense of childhood vaccination programs. “As countries cry out to get their hands on Covid vaccines, we have backed down on other vaccinations, putting children at risk of catching serious but preventable diseases like measles, polio or meningitis.”, recalled the Director General of WHO Tedros Adhanom Ghebreyesus. “Several epidemics would be a disaster for communities and health systems already battling Covid-19, making the need to invest in childhood immunization more urgent than ever”.

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In Vermandois, a family affected by Covid-19 tells

Covid-19

This family from a village in Vermandois kindly told us, on condition of anonymity, how they experienced and managed the Covid, which affected all members of the family, last May.

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“Open house” vaccination available for those over 40. Janssen batch suspended in Mafra due to adverse reactions | Coronavirus


to the minute

There are 4153 new cases of covid-19 in Portugal and nine more deaths. Ordem dos Médicos presents a new indicator of the evolution of the pandemic. More than half of Portuguese people have already received at least the first dose of the vaccine and 42% have been fully vaccinated. There are 476 active outbreaks in mainland Portugal. Vaccination in children and adolescents continues to divide experts.

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between pro and anti-vaccines, an electric dialogue

“And you, are you planning to get vaccinated?” “ Ludivine (1), psychologist in Burgundy, often asks the question to his patients. And, whatever the answer, try to listen without judging. This vaccine from the first hour, on the other hand, is much less comprehensive when the reluctance comes from professionals in contact with vulnerable people.

→ ANALYSIS. Covid-19: Emmanuel Macron forces the hand of the unvaccinated

“The other day, during a session with educators, I suggested that the vaccine would allow us to do without the mask in September, she says. One of them replied: “It won’t go through me!” Not only will we have to continue to wear the mask, but in addition, it endangers the disabled people with whom it works. “ At the time, she made no remark. ” What’s the point ? The positions on this subject are too clear-cut, it will inevitably lead to a conflict. “

How many similar scenes of tension have taken place in recent weeks, while the deterioration of the epidemic situation increases the pressure on those resistant to vaccination, in particular among caregivers? A nurse in an Ehpad in Moselle, Mélodie, too, has given up on dialogue. “In my establishment, the rare nurses or nursing assistants who do not want to be vaccinated float in the conspiracy and very often, vote at the extremes, explains the young woman. I don’t want to argue with them. “

The freedom to say no

If the break between vaccinated and non-vaccinated is sometimes based on political opposition, it is above all sociological, according to epidemiologist Yves Buisson. “Among caregivers, the refusal often comes from people less educated or less high in the hierarchy”, recalls this member of the National Academy of Medicine. A resistance that can partly be understood: “These people have done everything that was asked of them for a year and a half. For the first time in a long time, they have the freedom to say no. “

→ MAINTENANCE. “The freedom given back can be taken back from us at any time”

A freedom that Camille claims, for whom vaccination is “An experimental madness when 99.5% of people recover from the disease and there are treatments”. This tourism professional, who refuses to be taxed“Irresponsibility” and “egoism”, proclaims: “We do not want to hear from each other but we are full citizens”.

If their lack of altruism is often reproached to them, the refractories, them, denounce the intolerance of their “adversaries”. For Sandrine, retired in the Camargue, “It is particularly difficult to discuss with pro vaccines, so formatted by the ‘mainstream’ media that they have become deaf to any other information”.

Not the same language

For the sociologist Gérard Mermet, if these two “camps” have such difficulty in communicating, it is because they do not speak the same language. “People who defend vaccination are based on scientific arguments, opponents on impressions, fears, even the most irrational conspiracy”, he sums up, speaking of “Moral fracture”.

“In the end, everyone considers that they are in the camp for good and that it is the others who are dysfunctional”, confirms historian Laurent-Henri Vignaud, lecturer in modern history at the University of Burgundy. At the risk that this moral condemnation will lead to a form of witch hunts.

“The unvaccinated become scapegoats who would be the only culprits of the epidemic and that we are going to track down”, warns the historian. “In the Middle Ages, people were thrown into wells because they were considered responsible for the plague”, also warns Annick Opinel. For this historian and philosopher of science, the radicalization of discourse on both sides is fueled by an unprecedented sense of urgency: “Usually, the issues of vaccination are more abstract, this time, we can see them with our own eyes: it is the terraces and cinemas that have reopened, life that has resumed… Such an effect of reality had not seen himself before, and feeds the vexation of the vaccinated. “

→ ANALYSIS.Covid-19: the challenges of an obligatory vaccination for all

Anger which, on social networks, often turns into anger. “Frankly the antivax … You never get tired of being idiots? “, got carried away by an Internet user on Twitter, responding to a message from a user assuring that the death of geneticist Axel Kahn, suffering from cancer, was “Accelerated by vaccination”.

The right to ask questions

“I present to you a real fool, endowed with only two neurons”, comments another, in reaction to the video of a caregiver opposed to the vaccination obligation. “The problem is that social networks have removed any hierarchy between information, points out Doctor Olivier Jourdain, author ofInvestigation in the country of antivax (Crop). An article in a scientific journal will be put on the same level as an anonymous message. ” The doctor however wishes to distinguish the anti-vaccines and the hesitant, claiming the right to question.

“I fully understand that we can ask questions, but in this case, we have to look for answers! “, Agnès Abt-Salmer annoys. This Frenchwoman living in Russia, very active on Facebook to defend vaccination within the expatriate community of Moscow, admits “End up being violent in (his) about “.

→ PRACTICAL. A summer under Covid: the answers to your questions about vacations

“On social networks, conversations boil down to arguments and counter-arguments, without everyone really reading themselves, she regrets. Fortunately, in society, we are more respectful of each other… ”

Especially since the skeptics are not always where they are expected. Chloe has just discovered that her companion was among the hesitant. Fear of side effects, worries about “Lack of perspective”“After everything we have been through for a year and a half, we are lucky to have a vaccine and he does not get it”, annoyed this Parisian who put this subject aside, to avoid a new argument.

« It’s unsettling to see that reasonable people, usually in favor of vaccines, oppose it this time around, underlines Annick Opinel. While it is not difficult to brush aside conspiratorial rhetoric, it is more difficult to counter more moderate resistance. “

Because this is a specificity of this crisis, which gives rise to unsuspected dissensions. “There are not two opposing camps, but a multiplicity of points of view which diverge on certain points, relativizes Anne-Marie Moulin, doctor and philosopher. Of course, this does not simplify relations, but it also means that there can be bridges… ”

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Vaccination, where are we?

As of July 8, 52.75% of the French population has received at least one dose of the Covid-19 vaccine and 39.33% is fully vaccinated, according to the Ministry of Health.

Among young people, 17% of adolescents between 12 and 17 years old, and 48.17% of 18-29 years old received a first dose.

Among the oldest, those over 75 are 85.3% to be at least partially vaccinated. 89% of nursing home residents have received at least one dose of the vaccine and 83% have a complete vaccination schedule.

Among professionals, those working in nursing homes were 61%, on July 5, to have received at least one dose. The figure rises to 81% among liberal health professionals. As of May 31, according to the latest data published by Public Health France concerning professionals working in establishments (hospitals or clinics), 63.5% were at least partially vaccinated.

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