They celebrate in New York and California: they dismiss the restrictions due to coronavirus, by vaccinating more than 70% of adults

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Deyanira Batrezchavez, 23, kisses her dog Chandler, held by her boyfriend José Banegas, 23, in a kissing booth, part of a reopening party held as restrictions on coronavirus disease are gradually lifted in Los Angeles, California. REUTERS / Cheney Orr

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Alzheimer’s disease: iron nanoparticles in the brain

WFor the first time, scientists have detected nanocrystals made from pure iron and copper in the brains of deceased Alzheimer’s patients. It is still unclear what role these metals may play in the development of the disease. Researchers hope that Alzheimer’s can be diagnosed earlier in the future. In any case, the surprising research result opens up a new lead.

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Alzheimer’s disease: iron nanoparticles in the brain

WScientists from Germany, Great Britain and the USA have discovered a new lead that could potentially lead to a better understanding of Alzheimer’s and how it develops. It has long been known that the disorder associated with memory disorders is associated with deposits of insoluble proteins in the brain. At least these so-called plaques, also known as amyloids, can be detected in the brains of deceased Alzheimer’s patients.

Scientists from TU Darmstadt, the University of Warwick, the University of Keele, the University of Texas in San Antonio and the Case Western Reserve University now report in the journal “Science Advances” that they have for the first time detected nanoparticles made of copper and iron in such plaques .

“The size of these particles is a few tens of nanometers,” explains Professor Frederik Lermyte from TU Darmstadt, “it was a great surprise for us to discover these metal particles in brain tissue. This is really new. “

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It has long been known, however, that water-soluble compounds of copper and iron play a role in brain metabolism. In their investigations, however, the researchers not only came across such molecules, but also insoluble nanoparticles made of pure metal.

The scientists used a number of measurement methods to prove this, including mass spectroscopy and X-ray absorption spectroscopy. The X-ray measurements were carried out on synchrotron radiation sources in England and California.

The connection with Alzheimer’s is unclear

Whether and what connection there is between the existence of nanoparticles in Alzheimer’s plaques and the development or progression of the disease remains an open question for the time being. Lermyte believes it is very likely that the metal particles influence biochemical processes.

“It is known that metallic nanoparticles have the effect of a catalyst and promote certain reactions,” explains the chemist, “in addition, it is likely that the chemical reactions that lead to the formation of these metal nanoparticles also give rise to reactive oxygen species, which are toxic to the cells of the brain. ”These mechanisms now need to be researched in detail.

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Graphic of an Alzheimer's affected brain

Because some are now speculating whether the ingestion of too much copper or iron with food could be a risk factor for Alzheimer’s, Lermyte emphasizes that water-soluble copper and iron are naturally required in the brain and are involved in metabolic processes there.

However, there seems to be no reasonable reason for the existence of metallic copper and iron in the brain. The crucial question is rather: Why are the discovered nanoparticles formed? And could that be a cause or just an unimportant accompanying circumstance in Alzheimer’s?

The diagnosis could be possible earlier

Lermyte thinks it is conceivable that the findings of this research could result in the possibility of a very early diagnosis of Alzheimer’s disease.

If the metal particles were to form in a very early phase of Alzheimer’s disease, a correspondingly early diagnosis would be possible because the nanoparticles could be detected with a sensitive magnetic resonance tomograph. But would it even make sense to find out about this impending fate ten or twenty years before the first symptoms appear?

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Alzheimer

“I wouldn’t even want to know,” says Alzheimer’s researcher Mathias Jucker from the Hertie Institute for Clinical Brain Research at the University of Tübingen, “at least not as long as there are no effective drugs available that can actually prevent the disease.”

This drug could be a game changer

The antibodies approved as Alzheimer’s drugs in the USA in June 2021 could possibly be a “game changer”, says Jucker, “but on the one hand they are not yet approved in Germany. And on the other hand, this antibody can at best postpone the disease but not prevent it, but it is quite possible that there will be antibody drugs that work even better in the years to come. “

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Gehrin

When it comes to new insights into iron and copper, Jucker is reluctant. “Yes, that is a very interesting research result, but the plaques in Alzheimer’s brains are, as it were, the gravestones of the disease process. Hundreds of things can be found in them and then you still have a long way to go whether these substances played a role in the development of Alzheimer’s. ”

Jucker points out that conspicuously high concentrations of aluminum were detected in Alzheimer’s plaques as early as 30 years ago. And to date there is no convincing evidence that aluminum increases the risk of Alzheimer’s disease.

For Alzheimer’s researchers, there are now definitely new leads, new hypotheses and a lot of work. How quickly and whether useful knowledge will emerge from this is open. In basic research, you never know what will come out in the end.

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Republicans are calling for virologist Anthony Fauci to be fired

Virologist Anthony Fauci has repeatedly come under fire in the corona pandemic, not least from ex-US President Trump. Now several politicians are raising again allegations – and calling for his dismissal.

Photo series with 19 pictures

Several US Republican MPs are pressing for the dismissal of the renowned corona expert Anthony Fauci. The group, led by Congresswoman Marjorie Taylor Greene, proposed a Fire Fauci Act on Tuesday. They accuse the immunologist of having misled citizens with his statements and making conflicting recommendations on the need for masks and distance.

They also accused the experts of lying about the origin of the virus in Wuhan, China, where the pathogen first appeared in late 2019. You are referring to a number of Recently leaked email from Fauci. The bill has no chance of implementation in the Democratic-controlled Congress.

“He wasn’t elected to run our economy”

“Dr. Fauci was not elected by the American people. He was not elected to run our economy. He was not elected to determine parents and the upbringing of their children,” said the controversial Congressman Greene, on several occasions through extremist remarks noticed in front of journalists. “But even so, Dr. Fauci had very strong control over our lives over the past year.”

Fauci, who has advised seven US presidents in his career, was a member of the corona crisis team of former President Donald Trump. With his great expertise and his unvarnished assessments of the corona pandemic, the immunologist gained great public recognition. At the same time, he repeatedly incurred the resentment of the president, who had downplayed the danger posed by the corona virus from the start. US President Joe Biden made Fauci his chief medical advisor.

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New outbreak of coronavirus in China threatens global shortage of goods

The new outbreak of COVID-19 in southern China, coupled with a rapid global economic recovery and a shortage of shipping containers, has triggered a sharp rise in transportation costs that could trigger inflation and shortages of goods around the world.

China on Wednesday reported 21 new cases of coronavirus in the mainland, with 15 in the vital industrial province of Guangdong, where restrictions have been in place for several weeks to contain an outbreak related to the Delta variant first detected in India.

According to The Guardian, there are currently 150 cases of the “Indian” variant, mainly in the city of Guangzhou, and due to the blockage, a major port of that city has been badly damaged. A separate outbreak of coronavirus in neighboring Shenzhen (not believed to be a Delta option) has also exacerbated the problem. These ports are among the top five in the world, and as a result, the cost of shipping goods has increased dramatically.

Shipping a 12.2-meter steel container by sea from Shanghai to Rotterdam costs a record $ 10,522, nearly 300% more than last year, according to Drewry Shipping.

Factory costs in China are already up 9% in May – the most in more than a decade – due to rapid demand growth as the global economy resumes and supply chain disruptions are resolved.

Financial markets are also worried about the specter of rising inflation after US consumer prices rose at their fastest pace since 2008 last month amid a dizzying economic recovery from the pandemic-triggered recession.

Rising demand for goods has boosted prices for everything from food to cars and household items, The Guardian writes.

Investors believe the US Federal Reserve may view rising inflation as a sign that it should start scaling back its extensive monetary stimulus program and weaning stock markets away from perennial ultra-low interest rates.

Supply chain expert Flavio Romero Macao says stopping in China would normally not be a major problem. But when combined with other factors, this means that the prices of manufactured goods and goods could rise significantly over the next three to five years, as shipping companies are forced to recoup their costs.

“Major players work with pre-established contracts, not spot prices, so the current problems will not be repeated now at higher prices,” the expert said. “But over time, costs will increase, and this increase will be constant over the next three to five years, because shippers will have to recover their costs.”

Shipping restrictions were also in full swing prior to the latest coronavirus outbreak in China, as the post-pandemic race to start shipping goods triggered a container shortage, exacerbated by the blockage of the Suez Canal in March.

Ports in China’s Guangdong province, including Yantian, Shekou, Chiwan and Nansha, have banned ships from entering ports without prior reservations and will only accept orders for export containers for three to seven days before ships arrive.

Major shipping companies warned clients about ship delays, changes in port calls and the possibility of skipping some ports altogether.

The world’s leading container line, Maersk, said it has increased expected delays in Yantian from 14 days to 16 days.

“One of the largest ports in China is practically closed for almost three weeks. They have several operating berths, but they are not enough, ”Niels Haupt, director of public relations for the German shipping line Hapag-Lloyd, told the BBC. Vessels are being rerouted to other ports, including Hong Kong, but that will not be enough to keep up the lag, he said.

Flavio Romero states: “There was such a rapid recovery after COVID when people were spending money like crazy on TVs, set-top boxes, cars, etc. The system was out of balance. COVID has created a big puzzle and it will take a long time to put it together. “

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“Waiting for miracles” – Biden meets Putin in Geneva – world

The conflicts between the USA and Russia have come to a head. The Geneva summit could de-escalate, but both sides are dampening expectations.

On Wednesday, the world will look spellbound to Geneva: US President Joe Biden and Russian President Vladimir Putin will meet there for the first time. While Biden’s Airforce One landed in Geneva on Tuesday afternoon, Putin will not arrive until Wednesday.

Ex-President Trump tried to score points with Putin with his pro-Russia policy at the Helsinki summit in 2018. No US president had humiliated himself more pitifully in front of a tyrant, criticized US politicians.

With Joe Biden, Putin is likely to face a different wind in Geneva. Because the relationship between the two great powers has long been – and even more so since Biden took office – reached a low point.

“Killer”, sanctions and Navalny

After Biden called Putin a “killer” in an interview in March, Moscow called its ambassador to the United States back. Putin’s spokesman said that there had never been such a statement by a US president. Apparently, Biden does not want to improve relations with Russia.

Various Russian hacker attacks on US infrastructures, authorities and NGOs recently made headlines. Putin reacted to the US sanctions by imposing entry bans on high-ranking US government officials and expelled ten US diplomats. In May Moscow officially classified the US as an “unfriendly state”.

Another point of contention for years has been the alleged Russian interference in the US presidential election. When it comes to human rights, Biden is likely to focus primarily on the Navalny case. Kremlin critic Alexey Navalny was the victim of a poison attack in August. After treatment in Germany, he returned to Russia, but was sentenced to camp imprisonment there. Putin has classified his regional support network and his anti-corruption foundation as “extremist” and banned them with immediate effect.

“Central Event”

In addition to geopolitical conflicts such as the Syrian war or in eastern Ukraine, both countries accuse each other of violating international agreements. Trump, for example, announced an important agreement, the Intermediate-Range Nuclear Forces Treaty, which regulates the disarmament of medium-range nuclear missiles.

For its part, Russia canceled the Open Skies security agreement on international observation flights a few days ago. The US withdrew from the multilateral treaty last year.

Can the meeting, like the Gorbachev-Reagan summit in Geneva in 1985, bring the two warring superpowers closer together and de-escalate them? The Russian newspaper “Nezavisimaya Gazeta”, which is close to the Kremlin, described the meeting as a “central event in world politics”.

Will disarmament come about?

Arms control in particular is the focus with the aim of preventing tensions from degenerating into war. Russia currently has an estimated 1,570 deployable nuclear warheads and the US 1,750.

“It would be desirable to define a roadmap for bilateral relations with an emphasis on arms control. May there just be no war,” writes the “Nezavisimaya Gazeta”.

Meanwhile, both sides are dampening the high expectations. The Moscow magazine “Russia in Global Politics” summed it up like this: “Everyone is waiting for a miracle.” At least Putin and Biden seem to understand that tensions should not increase any further. Yuri Ushakov, Putin’s foreign policy spokesman, described the situation as “almost critical”. You have to do something. The meeting is a first step. And US Secretary of State Antony Blinken: It is important to talk to each other despite differences.

Nav-Account 20 minutes Time| Akt:

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Biden and Putin praise constructive summit, play appeasement

Joe Biden and Vladimir Poutin praised their constructive exchanges on Wednesday at a summit in Geneva, showing their desire to ease tensions while remaining stingy with concrete announcements.

“There was no animosity (…) It was a frank and direct discussion”, estimated the Russian president at the end of the meeting, while his American counterpart evoked, during a press conference distinct, a “positive” tone.

In a clear break with the procrastination and ambiguities of his Republican predecessor, Donald Trump, the Democratic President assured to have clearly warned the strong man of the Kremlin, in particular on cyberattacks.

He announced that he had sent his counterpart a list of 16 “critical infrastructures” (energy, water supply, etc.) which were “untouchable” in his eyes. And assured that the United States could respond with the same weapons in the event of a “cyber” attack.

He also assured that he would not tolerate “attempts to destabilize our democratic elections”, in a reference to Russian interference in the 2016 presidential election.

Asked, when he had finished his press conference, on the reasons why he thought that Putin was going to change his behavior, he got carried away, assuring that he had never hinted at such a thing.

– Return of the ambassadors –

The only concrete sign of a certain thaw, Mr. Putin said he had agreed with Mr. Biden on the return of their respective ambassadors, recalled earlier this year for consultations. He also ruled that a “compromise” on a prisoner exchange was possible.

The two leaders also spoke of a future dialogue on “cyber-security”, while remaining evasive on its outlines.

Joe Biden? “I can say that he is a constructive, balanced person (…) and that is what I expected”, commented Mr. Poutine.

Vladimir Poutine? “He’s not looking for a Cold War with the United States,” Biden commented.

But the two leaders also exchanged a few pikes, by interposed press conferences.

While he admitted that the two men had raised the issue of human rights, Vladimir Putin immediately embarked on a long diatribe against the United States on this theme: from the attack on Congress on January 6 to a bombing of civilians in Afghanistan through police violence against the African-American minority.

This exit provoked, half an hour later, a sharp retort from the American president who denounced “ridiculous comparisons”.

“Putin is, without a shadow of a doubt, still Putin after this summit,” stressed in a tweet Ben Rhodes, former close advisor to Barack Obama on foreign affairs.

When the fate of the opponent Alexeï Navalny, now imprisoned after seeing the near death of a poisoning which he accuses the Kremlin of having instigated, Mr. Putin simply declared: “This man knew he was breaking the law in force in Russia “.

Joe Biden this week issued a warning about the opponent. Navalny’s death “would only deteriorate relations with the rest of the world. And with me,” he said.

– “Two great powers” –

Joe Biden had proposed at the beginning of the discussions to his Russian counterpart more “predictable” relations between the United States and Russia, believing that “two great powers” should manage their disagreements in a “rational” way.

The first summit between the two men – a little shorter than expected – ended at 5:05 p.m. (3:05 p.m. GMT) in Geneva.

The White House claimed a twofold objective: to explore possible avenues of cooperation and to deter Putin from continuing his “destabilizing activities” around the world.

“We try to determine where we have common interests and where we can cooperate. And when this is not the case, to establish a predictable and rational way to manage our disagreements”, explained for his part the American president, at the beginning. of the discussion.

“Two great powers,” he added, in marked contrast to the words of former Democratic President Barack Obama who had described Russia as a “regional power”.

The Russian president can rely on a long experience: he has already rubbed shoulders with four other American presidents since coming to power at the end of 1999.

Many experts agree that, even before the summit was held, he had obtained what he most wanted: a meeting highlighting the importance of Russia on the world stage.

The summit was expected to last between four and five hours, but the delegations finally parted after about 3.30 hours.

For Republican Senator Lindsey Graham, the words of the American president were “disturbing”.

“I think President Biden misjudged who he was dealing with,” he tweeted.

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Watch – sexual intercourse while she is in photography.. a beautiful artist who did not control her instincts!

Thank you for reading news about watching – sexual intercourse while in photography.. a beautiful artist who did not control her instincts! And now with the details

Aden – Yasmine El Tohamy – Turkish actress Handa Archil, the heroine of the series “You’re Knocking on My Door,” shocked her audience on the social media with dangerous confessions.

Where Archil admitted that she had real sex more than three times with the hero of the movie Weeping Eyes (Turkish movie).

She said that she was completely naked during her performance in the film, noting that the necessity of work required that and that she does not regret her participation in the film Weeping Eyes.

The Turkish actress, who has more than two and a half million followers on Instagram, considered that the message the film presents is more important than anything.

Hande Archil, born in 1993, in the Turkish province of Balık Asir, graduated from Mimar Sinan University of Fine Arts, and began her artistic life in 2014, through the series “Crazy University”.

As for her real fame, she gained her through her embodiment of the role of “Celine” in the series “Daughters of the Sun” in 2015.

It is noteworthy that Handa Rachel is a star that ranked first in Turkey and occupied the world press with her beauty and also occupied the Turkish press with her emotional stories, especially after her separation from her lover, the Turkish singer Murat Dalkilic, because of a hot kiss with actor Karam Bursin, who is co-starring in the series You Knock on My Door.

The series You Knock My Door enjoys a high public follow-up because of its events that revolve in the form of a romantic comedy, and the distinguished performance of the youth heroes Karam Bursin and Handa Archil, which makes it achieve high viewing rates, as the audience is keen to watch its new episode as soon as it is shown.

And Handa Archil, the heroine of the series “You’re Knocking on My Door,” shared her followers a few days ago, new photos of her on the Instagram photo and video sharing site.

And Handa Archil appeared in the photo, with a charming look, as she wore a short red dress, which attracted the attention of her followers.

She did not bother to acquire accessories and was satisfied with her distinctive look and left her hair in an attractive way, which suited her look.

Aesthetically, Handa adopted no makeup and was satisfied with her distinctive look.

The Turkish actress, Handa Archil, shines in the selection of her clothes, which prompts her followers to express their love for her appearance, as she shares photos with them through the “Instagram” application.

The 25th episode of the summer Turkish series, “You’re Knocking on My Door”, was criticized for its high levels of viewership, due to the coldness of the events it carried. The audience described its events as “fabrication,” noting that the new writers were unable to make a qualitative shift in the way events were presented or constructed.

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After cutting aid to El Salvador due to a blow to the Judiciary, USAID chief meets with Nayib Bukele

The administrator of the US aid agency, Samantha Power, expressed her concern to Bukele about the deterioration of democracy in the country.

This morning, the administrator of the United States Agency for International Cooperation (USAID), Samantha Power, said that she had a meeting with the President of the Republic, Nayib Bukele.

In this, according to Power, the concern about democratic governance in El Salvador was discussed.

“Constructive meeting with President @nayibbukele. We had frank conversation about many issues, about the support of @USAID to the Salvadoran people and about some #EEUU concerns about democratic governance, ”the official wrote on Twitter.

You can read: Corruption keeps foreign investment away, says USAID director

His visit to El Salvador is part of the first international trip of the head of US cooperation and a member of the National Security Council of President Joe Biden. This took place only a month and a half after the ruling party struck the Judiciary and took over a Prosecutor’s Office that was investigating possible acts of corruption by the Bukele administration.

Therefore, on May 22, USAID announced that it was withdrawing its cooperation from the Supreme Court of Justice, the Prosecutor’s Office, the National Civil Police that operated and carried out the coup, and the Institute for Access to Public Information that has been taken over by the officialdom.

These funds will be redirected to civil society organizations that fight corruption and promote democracy, the cooperation agency added.

While there are no further details of the meeting between Power and President Bukele, she stated in her tweet that “I appreciate your willingness to find a better route to the future.”

Also read: USAID will donate $ 30 million for job training programs in El Salvador

The United States has called on Bukele to restore democratic order before the May 1 coup, when it took control of the three powers of the State and the Prosecutor’s Office, but the president said that the changes were “irreversible”, something that has further strained its relationship with Washington, El Salvador’s main partner.

In addition to meeting with Bukele, Samantha Power was in a meeting with organizations that fight against corruption at the José Simeón Cañas Central American University (UCA), where she criticized the dismantling of El Salvador’s anti-corruption apparatus and regretted that the blows to the State of rights drive away confidence and investment in the country.

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