Researchers warn against vaccination euphoria: Optimism makes you careless

People tend to be careless when faced with good news, one study shows. This does not bode well for the corona vaccinations.

The second entry is still missing in this vaccination certificate. Just one dose is not enough Photo: dpa

STOCKHOLM taz | The expectation of getting vaccinated soon can make people dangerously careless. This is shown by the Swedish research study “Anticipation of COVID-19 Vaccines reduces social distancing”, which the Research Institute of Industrial Economics has now published. The researchers fear that the virus could spread even more quickly.

“Positive information about the effectiveness and accessibility of a vaccine reduces the will to adhere to the recommendations for maintaining social distance and good hygiene routines,” summarizes economics professor Erik Wenström, co-author of the study: “They then believe that life will return to normal more quickly, which seems to reduce their awareness and willingness to follow the recommendations of the authorities. “

Such a reaction is not really surprising, emphasize the scientists. People like to be confident, preferring to look to the future with positive visions rather than worry. Social psychologists call this tendency “optimism bias”.

The crux of the matter is that “such vaccination optimism can lead to poor health behavior”. Politicians and health authorities should be aware of this, recommends the study: When vaccinations begin, no loosening of existing infection control measures is appropriate, but rather “stricter rules are required”.

Researchers wanted to get information quickly

The study was conducted between December 10 and 13, when the first emergency approvals of Biontech / Pfizer’s corona vaccine were received in several countries, an EU approval was announced for the period after Christmas and vaccinations started in the UK. In a survey representative of the population, the participants were presented with different scenarios for the upcoming vaccine development. They were then asked about the behavior they had caused. There were such significant differences between the group of people to whom the most optimistic scenario was presented and a control group that the decision was made to publish the study before a peer-reviewed test procedure and publication in a scientific journal, in order to publicize it and to be able to inform politics about them up to date.

That’s probably not a bad idea, as news from Denmark shows. According to their own statement, staff and residents of an old people’s home in Aarhus were in a “celebratory mood” after they had all been vaccinated on December 29th. Perhaps this party mood was a bit too boisterous, because a week and a half later three people from the nursing staff and six residents tested positive. A 35-year-old nurse even had to seek hospital treatment.

Not over after a prick

Jens Lundgren, professor of infectious diseases at Rigshospitalet in Copenhagen, emphasizes that the first vaccination sting should not mean that the corona problem is over.

Lundgren also warns against following the British example and extending the period between the first and second vaccine dose to 12 weeks in order to be able to vaccinate as many people as possible at least once, given the limited doses available. He considers such an approach, which is also being discussed in Germany, to be “deeply risky” because, among other things, it increases the risk of vaccine-resistant mutations.

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Ring, sleeve, bypass: what are these obesity surgeries?

“These people were morbidly obese. In a few months, they have lost between 40 and 70 kilos, and are discovering the joy of living in good health. ” The trailer forOperation renaissance, new M6 show airing this Monday night, promises to tell the story of how obese people “Morbid” have had bariatric surgery. Not surprisingly, the concept drew a lot of criticism even before its release. A petition launched by the collective to fight against grossophobia Gras politique, signed by 25,000 people, even calls for its cancellation.

While the medical management of obesity is considered “Insufficiently structured outside the hospital sector” according to the Ministry of Health, bariatric surgery is, for its part, a sector that is doing well. In ten years, the number of operations has tripled, reaching 60,000 per year in 2016, in some 500 establishments. In all, obesity affects, in France, 17% of the population, or 8 million people, according to the interministerial group on obesity led by the general direction of the supply of care, the general direction of health and health insurance. Among them, 500,000 people are affected by obesity “very severe” (2016 figures).

Reduce stomach, short-circuit the intestine

Three operating techniques are used in France, with a loss that would represent, depending on the technique, 40 to 75% of excess weight according to the Assistance publique – hospitals of Marseille (AP-HM). Public Assistance – Hospitals of Paris (AP-HP) places this average rather between 20 to 30%. The first two techniques, the sleeve (“Sleeve” in English) and the gastric band are said “Restrictive”. They limit the stomach’s ability to ingest food. In the case of a sleeve, the surgeon removes two-thirds of the stomach, so that the digestive system takes the form of a tube.

In the case of the gastric band, also called gastroplasty, a prosthesis reduces the size of the stomach, creating a limited pocket that receives food. Third operation, the bypass (“Bypass” in English) is considered a mixed operation: it shrinks the stomach and bypasses part of the intestine by directly connecting the top of the stomach to the middle of the intestine.

Read alsoGrossophobia: “We fat people, we carry our suffering on us”

These operations are not “Not harmless” according to Health Insurance. If the operation is reimbursed, postoperative nutritional, psychological and sports monitoring is the responsibility of the patient. Only people 18 to 60 years old, with a body mass index (BMI) of 40 kg / m2 or more, can claim it. This threshold can be lowered to 35 kg / m2, if the person has a comorbidity that could improve after the operation (diabetes, high blood pressure).

Validated by a protocol comprising an appointment with a surgeon, a dietitian or nutritionist and a psychologist, the operation can finally “Be considered only if the person has tried, unsuccessfully, to lose weight thanks to specialized medical treatment for several months”, says Health Insurance.

38% failure

However, in 2016, the High Authority for Health noted that only 6 out of 10 operated patients had received a sufficient preoperative assessment, with an examination. “Of their comorbidities, endoscopic and psychological”, stages judged “indispensable”.

“This surgery is systematically offered for weight loss. However, when we know nothing about it, we might think that it is extensive cosmetic surgery, like liposuction ”, Gabrielle Deydier alert, author of the book We are not born fat (Goutte d’or editions).

Read alsoBooming obesity surgery suffers from very poor follow-up

Beyond the physical risks, which are not the least – infections, hemorrhages, ulcers, stomach leaks, nutritional deficiencies, acid reflux, inflammation of the esophagus … – a 0.1 to 2% risk of death according to the Lille University Hospital, and 38% of these surgeries fail, leading to weight gain, the risks are also psychological.

“Patients go through a ‘honeymoon’ period first, during weight loss. They are able to move and dress better, they are complimented, even if from a health point of view, they say they are tired ”, explains Sylvie Benkemoun, president of the think tank on obesity and overweight (Gros) and clinical psychologist in Forcalquier, in the Alpes-de-Haute-Provence.

This new body, this stranger

Then comes another phase, the loss of bearings, the long-term imbalance: “You have to live with this new body, which is foreign”, adds the latter. The pounds have disappeared, not eating disorders such as binge eating (eating without making yourself vomit or taking a laxative), which is widespread in people who have operated on.

Depression is also common in those who have had surgery, as is the shift from food addiction to alcohol addiction. Divorces are exploding, affecting one in two patients. You have to manage “A new relationship with others. It’s painful to feel like before, and yet to see that you are more courted, that you have more interest than before ”. For the psychologist, “The growth was a system of defense. When it is removed without precaution, the person is very vulnerable ”. Worse, some even go as far as suicide. According to Gabrielle Deydier, “Suicide is four times more important in people who have been operated on than in non-obese people, and twice as much as in obese people”.

For the president of Le Gros, “Being attentive to complications and difficulties, however, is not to pass judgment but to alert, so that things go as well as possible”.

Miren Garaicoechea

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sometimes difficult to manage emotions

PSYCHOLOGY – Beyond the well-known bodily and hormonal changes, the adolescent brain is also undergoing profound changes. With significant emotional consequences.

Risky behavior, heightened emotions, conflicts with adults, merging with friends… The time for adolescence has come, with the procession of behaviors that accompany it. But what if all these attitudes can be explained by the profound transformation that the adolescent brain undergoes during this period? In adolescence, the brain is like cut in half. “The regions of the brain that deal with emotions are mature. They are involved in sensitivity to emotions, the search for thrills and rewards. On the other hand, the brain regions that manage cognitive control have not completed their maturation. This system is involved in the regulation of emotions, resistance to automatisms and the control of actions, which makes it possible to act in an appropriate manner in the social world ”, details Marianne Habib, researcher in the psychology of cognitive development in the DysCo laboratory (University of Paris 8).

Thus, the difficulty of teenagers in controlling their sensitivity

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Cleaning as an art form: “We are slaves to our furniture” – style

Order makes sense. But the ideal of a sparkling clean home does one thing above all: It puts us under pressure, says the architects and artists “Honey & Bunny”. A conversation about cleaning.

Interview by

Violetta simon

Sonja Stummerer and Martin Hablesreiter, known as the artist duo “Honey & Bunny”, zoom in from the living room of an old apartment in Vienna. In their work, the two architects deal with the supposedly banal aspects of our everyday culture. In their first book “Fooddesign” they question our eating habits. In their new photo book “Cleaning – a cultural technique” they show a seemingly secondary activity in a new light. And come to surprising results: cleaning is political.

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When the avalanche of emails overwhelms us

PSYCHOLOGY – When they are too numerous, emails can become a living hell and cause mental difficulties as well as a drop in productivity at work.

It is 10:30 am and it is the umpteenth time that you have been interrupted by a “ding” indicating the reception of a new email. It’s the straw that breaks the camel’s back and you think you’ll never get to the end of this day. A common sentiment according to Caroline Cuny, professor of psychology at Grenoble École de Management: “The impression of not being able to manage all the emails received or of not being able to do the other tasks that we must perform during the day has an impact on our satisfaction at work and this will lower our feeling of self-efficacy . “

And if, as Bénédicte Pichard, occupational psychologist and ergonomist,, “The avalanche of mail cannot be the only one responsible for triggering a burn-out, it can contribute to it”. Indeed, when the brain receives too much stress it gets tired and “When it is too submerged, it no longer processes information as if it were switched off, like a circuit breaker”, precise

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Hope in Times of Corona: Instructions for Use – Knowledge

Confidence helps through bad times. But if you count on everything to get better soon, you quickly feel cheated. How to experience more joy in everyday life and learn not to dwell on expectations.

Of

Katrin Blawat

Sometimes a frog can help as a role model. That animal from Aesop’s fable that falls into a milk pot, has no idea of ​​the aggregate states of various milk products – and yet struggles with hope until it has stamped the milk into a solid piece of butter. The frog can climb out of the pot and into freedom.

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Taking care of your emotional well-being, a good new year’s goal

Yes, emotions are also talked about

In his opinion, to face the new year, again the most important thing would be to be aware that we have an emotional part, which is more instinctive and primitive and, in general, we tend to have it less developed and, above all, less known. “We have to restructure the idea that ’emotions are not talked about’, or that ‘it is not well seen to talk about emotions’. It is a limiting belief in society and it is an aspect to which we have to give the same importance as to thoughts or behaviors ”, he tells us.

And it is that you have to assume an idea once and for all: emotional health is a very important part of overall health. “It is proven that individuals who are aware of their feelings have better management of their thoughts and behaviors. And they have many more tools to deal with life’s events. In general, they are people who are well within their own skin, they are capable of maintaining a good relationship with themselves and a better relationship with others ”, he explains.

Read also: Being kind could be a super power

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Angelini Pharma to acquire Arvelle Therapeutics, creating a leading European innovator in central nervous system and mental illness therapy

Rom (ots/PRNewswire) Angelini Pharma, an international pharmaceutical company belonging to the private Italian Angelini group, and Arvelle Therapeutics, a Switzerland-based biopharmaceutical company specializing in the development of innovative therapies for patients with CNS disorders, today signed a definitive merger agreement. According to this, Angelini Pharma will take over Arvelle Therapeutics in a pure cash transaction for a total value of up to 960 million US dollars. Once approved by regulators, it will pay $ 610 million. An additional up to $ 350 million will be paid at a later date, subject to certain sales targets for Cenobamate being met.

Following the acquisition of Arvelle Therapeutics by Angelini Pharma, Angelini Pharma will receive the exclusive license to commercialize cenobamate in the European Union and other countries in the European Economic Area (Switzerland and Great Britain). After receiving approval from the European Medicines Agency (EMA), which is expected in 2021, Angelini plans to launch cenobamate.

Since inception in 2019, Arvelle’s management team has focused on making Cenobamate available to people with epilepsy in Europe while creating significant value for shareholders. You have worked closely with the European regulatory authorities to advance the marketing authorization application (MAA). In order to prepare for the market launch and ensure it in all key areas of the company, a Europe-wide organizational structure was also developed.

Cenobamate has been classified by the UK MHRA as a “Promising Innovative Medicine” for the treatment of drug-resistant partial seizures in adults. Cenobamate is a small molecule with a unique dual complementary mechanism of action. It has a positive effect by modulating the? -Aminobutyric acid (GABAA) ion channel and by inhibiting voltage-dependent sodium currents. Key studies documented the clinical effectiveness of cenobamate by showing a significantly greater reduction in mean seizure frequency and more patients achieving a reduction in seizure frequency of 50% or higher compared to the placebo group [1]. Cenobamate is approved in the US by the Food and Drug Administration (FDA) as an anti-epileptic for the treatment of partial (focal) seizures in adults and is available under the brand name XCOPRI® (Cenobamate-Tablets) CV.

“This is the most important investment in the history of our group and it illustrates the anchor shareholder’s commitment to the pharmaceutical industry, which is still our largest business area” commented Thea Paola Angelini and Sergio Marullo von Condojanni, Executive Vice President bzw. CEO der Angelini Holding. “This acquisition represents a milestone on our growth path and is a driver of our multinational orientation, which all companies in the Angelini Group are following. We are proud that we have succeeded for the second time within a year in acquiring a significant and coveted asset that strengthens us and positions us as one of the most important players in the market. “

“We at Angelini Pharma are delighted to have signed this promising agreement and are delighted with the commitment and work that our colleagues at Arvelle have put into the company over the past few years. We share the same patient-centered culture and agile attitude,” says Pierluigi Antonelli, CEO Angelini Pharma. “This transaction will make us a leading European player. We are well positioned to address the needs of patients with various diseases of the central nervous system through an innovative portfolio, strong medical skills and an extensive market presence – particularly through the opening of offices in France, Great Britain, the Nordic countries and Switzerland by 2022. “

“I am very proud of the team we have built at Arvelle and of the progress we have made over the past two years to bring cenobamates to people with epilepsy in Europe”, said Mark Altmeyer, President & CEO von Arvelle Therapeutics. “We believe we are an excellent strategic fit for Angelini Pharma and believe that the acquisition of Arvelle and the launch of Cenobamate can help accelerate their goal of becoming a leader in the CNS industry.”

SK Biopharmaceuticals, a global innovative pharmaceutical company listed on the Korea Stock Exchange, announced that it has agreed to sell its 12 percent stake in Arvelle Therapeutics to Angelini Pharma. SK Biopharmaceuticals will continue to be entitled to all payments resulting from the license agreement signed between Arvelle Therapeutics and SK Biopharmaceuticals in February 2019. In addition, revenue sharing payments due to certain Arvelle shareholders will be paid by Angelini Pharma.

“We are excited to start a new working relationship with Angelini Pharma that will enable us all to take a step forward in introducing cenobamates in Europe – as we promised the epilepsy community”, said Dr. Jeong Woo Cho, CEO von SK Biopharmaceuticals. “This is not only the beginning of a new relationship with Angelini, but also the beginning of our market entry in Europe. We at SK Biopharmaceuticals will continue our efforts together with our partners to bring new treatment options to patients worldwide.”

Centerview Partners UK LLP is acting as sole financial advisor to Arvelle and Sidley Austin LLP and NautaDutilh NV as legal advisor. White & Case (Europe) LLP acts as legal advisor for Angelini Pharma, with the support of KPMG for the Due Diligence Tax & Accounting.

Logo – https://mma.prnewswire.com/media/1213125/Angelini_pharma_Logo.jpg

Logo – https://mma.prnewswire.com/media/1394109/Arvelle_Therapeutics_Logo.jpg

Inquiries & contact:

ANGELINI PHARMA: Daniela Poggio
Global Pharma Communications Head
Angelini Pharma
Mob. + 39 348.6558882
daniela.poggio@angelinipharma.com

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Gregory Crewdson, empty passages

It’s wet in all the footage in Gregory Crewdson’s new series. But not cold, in view of the outfits, light, worn by the characters who pose there, on the steps of their hut, on the steps of a bar, or on the threshold of a container, as if they were made of marble .

It is the hour when the streets, the backyards, the facades of the houses, and the hearts, no doubt, too. Because even if it’s no longer raining, everyone looks washed out. Nobody moves. No longer has the strength, no longer the desire, no longer the means.

Something each time hinders movement. A traffic light fallen in the middle of the road blocks the passage and the driver of this stopped car has certainly got out of his vehicle, but only seems able, with his hands in his pockets, to see that he will not pass. His companion, transient silent, does not flinch. No one passes. The cliché, however, opens up wide spaces. All images, taken in the New England area, are taken in a panoramic setting. We can see high and far, to the sides and from behind. But it is a paradoxical panorama which, widening the angle of view, narrows the place of the characters in an immensely desolate landscape. And where no one ventures, moves, emancipates.

Cul-de-sac

This is not surprising for the American artist, who has systematically staged, for twenty years, frozen bodies, beings lost in their thoughts, confused, struck by fate without us ever knowing exactly which one. , leaving the electrifying shadow of a fantastic phenomenon. But this exhibition at the Templon gallery differs from the previous ones (the last one dates back to 2016) in that all the scenes are taken outdoors. Usually, it is in the hollow of their bedroom, on the edge of the bed, or leaning on their kitchen table that the characters plunge into the mists of spleen. There it is outside. In front of a bar, a woman is breastfeeding her infant while looking elsewhere; at the edge of a railway track, boys in BMX have dismounted to watch for the passage of a train (which will not pass). In the cul-de-sac of a vacant lot, young people sitting in saggy sofas contemplate the emptiness of their existence. A photograph of the economic, psychological and physical depression of a declassified America, Crewdson’s works go beyond this realistic framework (even this sociological aim) by infusing an unreal atmosphere.

Moths

The paintings he stages could be images from a film of the end of the world and the haggard resurrection of the human species in the form of the living dead. But Crewdson freezes the story, suspends the events, fragments the scenes, isolates and separates the characters, while here and there the lights of the traffic lights and the lampposts, left on in broad daylight, seem to guide them at the same time as the blind. Crewdson thus entitles his exhibition, “An Eclipse of Moths”, after this phenomenon where the moths cluster in swarms, lost, under the beam of artificial lights. An allegory of the astounding power of photography.

Judicaël Lavrador

Gregory Crewdson An Eclipse of Moths Galerie Templon, 28, rue du Grenier Saint-Lazare, 75003. Until January 23. Rens. : www.templon.com

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