This family from a village in Vermandois kindly told us, on condition of anonymity, how they experienced and managed the Covid, which affected all members of the family, last May.
AstraZeneca and scientists at the University of Oxford are exploring the possibility of modify your COVID-19 vaccine to prevent the formation of unusual blood clots, according to a person with knowledge of the situation.
Scientists are conducting an early stage research on whether the vaccine can be modified in some way to reduce or eliminate the risk of the side effect, although there is no formal program or funding for research at this stage, said the person, who asked not to be identified because the research has not been publicly discussed.
Earlier this year, several countries discontinued use of the Astra vaccine after it was learned that some recipients had developed a rare combination of blood clotting in the brain with low levels of platelets, which proved fatal in a small number of cases. Regulators later confirmed that there was an association between the vaccine and the disease, so some countries such as the United Kingdom limited the use of the vaccine to certain age groups considered to be of lower risk.
An Astra spokesperson stated that the company was “actively working with regulators and the scientific community to understand these extremely rare thrombus events, including information to drive early diagnosis and intervention and appropriate treatment.” An Oxford spokesman did not immediately respond to a request for comment.
The research was first published by the Wall Street Journal, who said that J&J He was also looking for modifications to reduce the risk of clots. A J&J spokesperson declined to comment on whether they were conducting such investigations, noting in a statement that the company supports “ongoing research and analysis” to help raise awareness of unusual side effects.
Most blood clots with concurrent thrombocytopenia in the UK arose after the first dose of the Astra vaccine, which requires two doses. By the end of June, 399 cases had been reported to the British regulator, including 71 deaths.
Drug makers such as Astra and Oxford are also actively researching how their vaccines can be modified to better address variants of the virus. Astra previously mentioned that he hopes to have a new version ready for the fall.
All viruses mutant over time, but most changes have little or no effect; However, some become more important or add up causing variants that can influence their ease of spread, severity of associated disease or vaccine efficacy.
The appearance of variants that posed a greater risk to global public health led to the use of specific categories such as: variant of interest (BUTTER) and worrying variant (YOU). The letters of the Greek alphabet were chosen to avoid stigmas on the countries where they are detected. The four variants of concern are Alfa, Beta, Gamma Y Delta. The latter is the one that turns on the alarms at present due to its reinforced contagion capacity, which according to data from the WHO it is estimated at more than 60% compared to the original virus. This behavior puts health systems to the test again, and particularly those in countries with a low vaccination rate.
The doctor Alejandro Sánchez Flores, in charge of the Massive Sequencing and Bioinformatics Unit of the UNAM Institute of Biotechnology and member of the Mexican Consortium for Genomic Surveillance, clarifies that the variants have a different behavior depending on the population. The Delta variant was detected at the end of last year in India, where its presence is currently around 90% of new cases in this country, as well as in other nations such as Singapore, UK Y Russia.
Also read: Covid Delta variant outbreak detected in Zinapécuaro, Michoacán
The specialist explains that in the United Kingdom they had already suffered a displacement by Alpha, the first variant in which important changes began to be noticed, mutations that give the virus a faster transmission and escape the neutralization of antibodies, according to some cases observed in in vitro experiments. Sánchez points out that these are the characteristics that cause a variant to be called “of concern”, because when vaccinated people become infected this suggests a particular concern, as in the case of the United Kingdom with a high vaccination rate of around 60% and with a large number of cases of the Delta variant. “This establishes a possible relationship that he is escaping the immune systemBut this not only talks about the virus, but also about the behavior of a population and how these transmissions are caused ”.
Vaccine efficacy is a value calculated at the population level. The specialist says that they cannot be cataloged individually; the percentage refers to a population average of not being infected, but it does not depend only on the vaccine, it is not a shield against the virus. The possibility of coming into contact with the virus remains and although vaccines allow it to be neutralized faster, with new variants this neutralization will be affected.
“In laboratory experiments, antibodies They do not recognize the virus in the same way, so that weaponry is no longer so effective; However, there is another type of immune response generated by the vaccine that is by goal T, which is still effective and in any case the body will create the necessary antibodies to neutralize the variant. “After the vaccine is given, the body needs time to generate an adequate immune response. This is what happens in the UK with people who become infected: those who have a full vaccination scheme are not reaching hospitalization. The real problem is for those who have only one dose or are not vaccinated ”.
Also read: Chile will charge patient zero of the delta variant for attacking public health
Remember that this supremacy of a variant already happened in Mexico with lineage B. 11,519, which since October spread throughout the country and was responsible for the December wave. The HIM-HER-IT He did not classify it as a variant of interest because despite having been observed in the United States and Mexico, it did not have important outbreaks in other places, only in some places of Europe, What Denmark. “In Mexico that lineage is already being displaced by others, and although it is not yet the Delta variant, in the near future it could be. The ones most found in the country are the Alpha and Gamma variants ”. About 10% of new cases of SARS-CoV-2 in Mexico are identified as Delta, according to the system GISAID, a global science initiative that provides open access to genomic data of the coronavirus responsible for the pandemic of Covid-19.
Follow the virus’s footprint
Dr. Sánchez Flores is part of the Mexican Genomic Surveillance Consortium, formed by academic and governmental institutions to characterize the diversity of the SARS-CoV-2 virus and its spread and evolution in the country. Its objective is also to inform in a timely manner about the circulation of viral variants with mutations that have the potential to affect their transmissibility or virulence. Through the site MexCov2 It concentrates and analyzes the diversity of the genome of the variants of the SARS-CoV-2 virus that circulate in the national territory, information that is later shared with international bodies.
The so-called variants of concern are already circulating in Mexico, but their behavior in the populations is being monitored. “While it is true that the variants can put us in a situation of ‘starting over’, the difference is the vaccines and more knowledge of the virus. The vaccine protects us from not reaching death, but we are still in 12% of the population with a complete scheme and a little more than 20% with a single administered dose ”. He assures that with the movement of the new variants, not a 60-70% would be enough. “It should reach 87% of vaccinated as soon as possible,” he stresses. The WHO warns that countries with the lowest vaccination rates will be the most affected. On Uganda, for example, 66% of serious illnesses in people under 45 are attributed to Delta.
Also read: Pfizer and AstraZeneca vaccines neutralized Delta variant in 95% of study participants
Sánchez points out that another bottleneck is super contagion events. “These events are evident in different parts of the world, for example, it is very possible that a massive festival on the Ganges river with more than a million people gathered has caused the great wave that recently lived because each of these people could infect 400 more people after fifteen days ”. It specifies that it does not mean that all have been infected, but it is an approximate to analyze the magnitude. “Possibly 70% do not have serious symptoms, but with 30% that do, it is enough to collapse a health system.”
The specialist points out that, however, such a massive agglomerate is not needed to unleash super contagions. “It is important to remember that the vaccine is only one of the elements: mask, healthy distance and hygiene cannot be neglected. Highly crowded and poorly ventilated closed spaces must be avoided. This is the model of Swiss cheese, you cut it and it has holes, but when you cut several slices and join them together, the virus may pass one layer, but not the next, so the more slices, the less chance of infection ”.
In the holiday period, the risks of supercontagions among the younger population are more latent. “Not by going through a sanitizing mat, using gel and measuring your temperature, you can be locked in one place for several hours. There are already major rallies in several states. Ten of the 14 states with upturns have beaches and tourist places with a large national and foreign influx without having sanitary fences ”.
Also read: Delta variant of Covid-19 is on track to be dominant in the world: WHO
For the specialist, another supercontagion risk event could happen with the return to classes. “Hybrid schemes can work well, following the example of other countries where they have already been successfully applied, such as the so-called 4-10, successfully applied in Israel and Sweden. Starting with tests, everyone is assigned four days in class and ten at home ”. Explain that the days they attend school are more likely to be non-infective, in case of any contagion.
In the near future, says Sánchez Flores, in the face of virus variants, vaccine boosters will have to be of different technologies to enhance their impact, for example those of adenovirus with those of RNA or recombinant protein. On the other hand, minors will have to be incorporated into the schemes; Labs are already rushing this process and in fact Pfizer announced that in December they will have a vaccine ready for children from six months to 12 years. He warns that the government’s challenge will be to plan a strategy for this new stage. “The government has to be in close contact with scientists to receive these suggestions, to make the best decision on a health problem, but where economic and logistical agreements will be fundamental.”
10% of cases New SARS-CoV-2 in Mexico, approximately, are identified as Delta.
“Not by going through a sanitizing mat, using gel and measuring your temperature, you can be locked in one place for several hours.” Alejandro Sánchez F. Institute of Biotechnology UNAM
Washington, United States.
The braking in the rhythm of vaccination, caused by skepticism among part of the population, and the arrival of the delta variant has increased the number of cases in Covid-19 United States in the last week, what has been ringing alarms between health authorities.
“It is very clear that this is a terrible variant. It has much more capacity to be transmitted person to person, “he said Antony Fauci, chief epidemiologist of the White House, in an interview on ABC.
Despite USA is the country with the highest number of inoculations in the world, it is on alert for the worryingand increase in casess of the delta variant, which already represents more than 50% of infections nationwide and 80% in some states where the percentage of the vaccinated population ands low.
Fauci, however, remarked that “the good news is that the existing vaccines work well “against this variante.
In the last five days, cases of covid-19 They have once again exceeded the figure of 20,000 newspapers, something not seen in the US since last May.
Added to this rebound is the braking in the rate of inoculation in the country, where 67.5% of adults have at least one of the doses necessary for vaccination complete and 58.7% already have the comprehensive scheme.
The first vaccine was administered in the United States last December, and during the spring inject more than 3 million daily doses, a figure that now barely reaches a few hundred thousand.
This slowdown has caused the goal set by the US president not to be reached, Joe Biden, who marked the past July 4 cas the date to arrive at 70% of adults with one dose.
In addition, authorities have warned of growing regional disparity, with numerous states in the northeast of the country above that figure, while others, especially in the south, such as Georgia, Mississippi, Alabama and Luisiana, they do not reach 40%.
Fauci warned, in this sense, of the danger that the country is divided into “one that is vaccinated and protected and another that is unvaccinated and with A lot of risk”.
In Mississippi, where only 33% of the adult population isvaccinated, the delta variant is doing havoc.
“Delta it has taken us completely. We are seeing many outbreaks, “said Thomas Dobbs, state health director, in an interview with CNN, and noted the special incidence among the younger.
A recent survey by the insurer Kaiser Family Foundation indicated that 20% of adults in the country have doubts about vaccines, of which 6% said they would only get the serum if it is required at work and 16% that you do not plan to be vaccinated.
Aware of these problems, heto White House he has redoubled his efforts and has indicated that he will go “door to door” if necessary.
See: President of Paraguay arrives in Miami after recovering bodies of relatives in Surfside
The First Lady, Jill Biden, has embarked on a tour of these southern states to encourage vaccination campaign and to convince the skeptics, who, he claimed, consider that eThe virus is not “severe.”
And the president himself, Joe Biden, he pleaded last Tuesday to those who still resist being vaccinated against covid-19 qthat they do so in order to contain the delta variant.
“Please get vaccinated now. It works, it’s free, and it’s never been easier, or more important,” Biden said in a speech at the White House.
The United States is the country most affected in the world by pandemic, with more than 600,000 deaths. EFE
The European Union is “prepared” for the possibility of administering to the population a third injection of the vaccine against covid-19 from Pfizer/BioNtech, which the manufacturers have proposed, said, this Friday, the European Commissioner for Health and Food Safety, Stella Kyriakides.
“We are already prepared in case it is necessary, both at European level and for a common strategy” for the purchase and distribution of vaccines, declared the commissioner during a press conference in Madrid, alongside the Spanish Health Minister, Carolina Darias .
“We work continuously, but the decision on the matter will come from science,” explained Stella Kyriakides.
His team “is constantly working with the European Medicines Agency (EMA) and the European Center for Disease Prevention (ECDC) to adopt a position in the coming weeks or months,” he added.
Despite the progress of the vaccination campaign in the EU (65% of citizens received the first dose and 47% the two), the Cypriot Commissioner warned: Europe is “in a very fragile situation, due to the increase in cases seen in many Member States , following the Delta variant”.
“This is not a time to relax,” he insisted.
On Thursday, Pfizer and BioNTech announced that they will submit “encouraging results for a third dose of the current vaccine” to regulatory authorities in the United States and Europe.
The two companies thought that a third dose could boost antibody levels against the virus and also against the highly contagious Delta variant.
The US-based The Hill published an article noting that some scientists have warned that vaccine manufacturers are finding financial incentives to develop booster drugs and for the government to invest in more doses. And that US health officials have specified that it is not clear that a booster vaccine is needed.
Anthony Fauci, the US government’s leading infectious disease expert, reiterated on Thursday that two injections of the Pfizer and Moderna vaccines protect even against the Delta variant.
However, Pfizer pointed to data on the results obtained with the vaccine in Israel.
“As seen in real-world data published by Israel’s Ministry of Health, the vaccine’s effectiveness in preventing infections and symptomatic diseases decreased six months after vaccination, although the effectiveness in preventing serious diseases remains high,” he said. to Pfizer.
“Based on data that (Israel) has so far, Pfizer and BioNTech believe that a third dose may be beneficial within six to 12 months after the second dose to maintain the highest levels of protection,” the companies said, partners in the production of this vaccine.
Pfizer also indicated that it is preparing to begin clinical trials in August of a modified vaccine, specifically targeted at the Delta variant, if needed.
Still, the company needed, at the same time, that a third dose of the original vaccine might be the best option.
Following Pfizer’s announcement, the FDA and the Centers for Disease Control and Prevention issued a joint statement minimizing the need for a booster dose.
“Americans who have been fully vaccinated do not need a booster vaccine at this time,” the agencies said, adding that they are involved in a “strict, science-based process to determine whether a new dose will be needed.”
The agencies again emphasized that current vaccine regimens are effective. “People who are fully vaccinated are protected from serious illness and death, including variants currently circulating in the country, such as Delta,” the agencies underlined.
The covid-19 pandemic has caused at least 4,013,756 deaths worldwide, resulting from more than 185.5 million cases of infection by the new coronavirus, according to the most recent assessment made by the Agence France-Presse.
Either for business or for fun, if your next destination is Europe you have to take certain considerations, because travel on this continent, even for its citizens, is somewhat restricted due to the increase in infections, hospitalizations in some parts of that continent; however, in many of these nations the measures to tourists are not so restricted.
In recent days, one of the cases that became media was that of youtuber Luisito Comunica, who wanted to take his father to Europe, but being vaccinated with Sinovac, one of the Chinese vaccines against covid-19, was denied the trip, because it was not one of the immunizations authorized by that continent.
The European Union has spread that the only vaccines approved by its member countries are AstraZeneca, Johnson & Johnson, Moderna and Pfizer-BioNTech, so if you want to set foot on European soil you will have to have applied one of these immunizations.
According to the European Commission website, it will be the decision of each nation to accept or not tourists with another vaccine other than one of the four that the political community established in the rules.
“Member states may decide to extend it also to travelers from the European Union who received another vaccine,” he mentions on his website for doubts and questions.
A couple of days ago, the Green Digital Certificate or also known vaccine passport began to work, with which the European Union will allow its citizens to travel between countries in this community.
The certificate was approved in March and entered into force on July 1 and its objective is to allow tourist movements within this continental block, without the need to submit to restrictions such as covid tests or quarantines of several days.
In some countries like Mexico, some of the vaccines approved by these nations are not recognized by Europe to vacation in the country, so it is not that they do not allow you to pass to any of the nations that make up this union, but you will have some restrictions .
That is, if you have been vaccinated against covid-19 with vaccines such as Cansino or Sinovac, you will have to quarantine for a couple of days or present a PCR test, not antigens, in order to have free transit in Europe.
People between 18 and 29 years old begin to be vaccinated against covid-19 next week and strategies are being analyzed to convince younger people to get vaccinated, the task force announced this Thursday.
“The week that starts on July 4th is the estimated date for the start of vaccination, in descending order, for the age group from 18 to 29 years old,” he told Lusa, a source from the structure that coordinates the vaccination logistics. However, this Thursday opened self-scheduling for people over 30 years old.
According to the same source, at an early stage, vaccination of this age group will be done through central scheduling, with users receiving an SMS message or a phone call from the health services, but self-scheduling will gradually become available up to 18 years of age.
“Currently, some actions are under study that could be implemented to appeal to younger people for vaccination”, also said the task force coordinated by Vice Admiral Henrique Gouveia e Melo.
A study by the National School of Public Health at the Universidade Nova de Lisboa, released on Tuesday, indicates that 85.7% of young people between 16 and 25 want to be vaccinated, but 14.3% have not yet decided if they will receive the vaccine against the SARS-CoV-2 virus.
“It is in the population of working age, men and people with more education that there is greater resistance to taking the vaccine”, indicate the data from the covid-19 barometer of ENSP for the period between 11 and 25 June.
“As the older age groups are almost totally or partially vaccinated, the highest incidences of resistance to vaccination are now evident in the young adult ranges”, explained Ana Rita Goes, scientific coordinator of the barometer.
According to Tuesday’s data from the Directorate-General of Health, 6% of the age group between 18 and 24 years (49,206 people) have already received the first dose of the vaccine and 5% (35,621) have completed vaccination.
Currently, people aged 33 or over can schedule the vaccination against covid-19 on the platform of the General Directorate of Health for these appointments.
The decision of the Cerco vaccination center, in Porto, to allow people outside the current order of priorities to be vaccinated for two days, constitutes a “disobedience”. And Vice Admiral Gouveia e Melo wants to see consequences “quickly”. “It’s an act of indiscipline,” he says.
“I’ve never had a case of this magnitude, it’s the first time. This, for all events, enshrines a clear disobedience to the plan: someone with responsibility who decides, outside the plan, to innovate and vaccinate people who are not currently eligible for vaccination” , said Gouveia e Melo to journalists, during a visit this Friday to the vaccination center on the island of Porto Santo, Madeira.
“As soon as we heard about the case, we tried to collect data and collected it. In two/three hours, and as soon as we had the minimum amount of data, we made a report to our contact with the Judiciary Police and a report to the General Health Inspectorate to carry out an investigation”, he said, also referring that he spoke with the president of the Regional Health Administration of the North (ARS) “so that this would stop happening and that all the consequences of this act would be removed, which, for all intents and purposes, is an act of indiscipline”.
ARS North opens inquiry
ARS Norte has already confirmed to JN that it has opened an inquiry into what happened at the vaccination center that operates under the responsibility of the Porto Oriental Health Center Group, whose director, Dulce Pinto, JN is trying to contact.
“I can’t fire people, of course. I asked the structure to quickly take the consequences that have to be taken, because there has to be discipline. I’m a military, in a plane of this complexity, with this urgency and being massive, I have to discipline. This will have to happen one way or another,” said the vice-admiral.
The person in charge of the vaccination task force thus reacted to the episode of the last two days in which the Cerco vaccination center will have opened a vaccination period for people of any age group, despite the current rules in force.
“Vaccinating young people”
The president of the Parish Council of Campanha, Ernesto Santos, on whose social networks the open day of vaccination was disclosed, explained what happened to JN.
“Tuesday I was contacted by the director of ACES Porto Oriental, Dr. Dulce Pinto, who asked me to collaborate in publicizing the open vaccination. I asked her if it was free, for everyone, and she said yes, that it was necessary to start vaccinating the younger layers. Which I like a lot because we have situations in which young people are the great transmitters of covid. As always, we collaborate with ACES Porto Oriental. If there was a mistake or not, I’m the one who has to judge these situations”.
Contacted by JN, official source coordinating the vaccination process confirms the participation of the IGAS and the Judiciary Police and that this situation “indicates the practice of acts contrary to the rules and instructions in force”.
“Currently, users aged 30 years and over and in the open house modality are being vaccinated, by central appointment, by self-scheduling or by local appointment, users aged 50 or over, with no provision for vaccination of users below the age groups currently foreseen, except users with comorbidities defined in standard number 002/2021 of the DGS or other exceptions defined in the same standard”, explains the task-force.
The Food and Drug Administration (FDA), the federal agency in the US Department of Health and Human Services that is responsible for drug approval, announced this Wednesday that it will place a warning on the labels of vaccines against Covid. 19 produced by Pfizer/BioNTech and Moderna. The reason is the appearance of rare cases of inflammation of the heart muscle in adolescents and young adults who have received these vaccines.
According to The Guardian newspaper, the US Centers for Disease Control and Prevention (CDC) advisory groups considered that inflammation in young people is likely to be due to vaccines, but stressed that the benefits of administering these drugs continue to far outweigh the risks.
According to the CDC, patients who develop inflammation of the heart (such as myocarditis and pericarditis) after vaccination are “extremely rare” cases – mostly young boys – and generally have recovered from symptoms and are doing well.
Still investigating the supposed link between vaccines and this health problem, the CDC does not confirm, for now, that there is specifically a causal relationship between the two, but admits that there was a higher than expected number of adolescents and young people developing inflammation of the heart after taking the second dose of Covid-19 vaccine.
According to data provided by the US Vaccine Adverse Event Notification System, cited by The Guardian, there were 347 cases of heart inflammation in the week after taking the second dose of vaccine in boys aged 12 to 24 years (when the normal number expected in this age group in the country would be 12 or fewer cases).
The US Department of Health and Human Services has, despite everything, publicly underlined that vaccines remain safe and effective and called for the vaccination of adolescents and young people.
“We strongly encourage the vaccination of all people aged 12 and over who are able to receive the vaccine,” the body said in a statement.
Pfizer said it did not see a higher rate of inflammation in the heart than would normally be expected in the general population. Moderna said that it is aware of case reports of this type after the administration of the vaccines and assured that it is working on the assessment of the problem together with public health authorities and regulators.
READ ALL ABOUT THE COVID-19 PANDEMIC
Karina Braña Mojica, niece of the President of the Republic, Andrés Manuel López Obrador, died this Tuesday in Ciudad Victoria, Tamaulipas, due to health complications due to covid-19.
Braña Mojica, who is the sister of the local deputy elected by the XIV District by Morena, José Antonio Braña Mojica, died at the age of 42, a victim of complications from the new coronavirus.
Karina Braña Mojica stood out in participating in the campaigns of both Andrés Manuel López Obrador and her brother.
Party colleagues expressed solidarity with the family.
“I am very sorry for the death of Karina Braña Mojica, I send my sincere condolences and the wish of a prompt resignation for her family and loved ones, rest in peace,” the senator for Tamaulipas, Américo Villarreal Anaya, said on his social networks.
Karina is the daughter of Lucia Mojica Obrador, cousin of the President of the Republic, Andrés Manuel López Obrador.
In 2020, the Mojica Obrador family had already suffered the loss of Úrsula Mojica, her husband and a son, also suffering from the covid-19 disease.
News about covid-19: Mexico registers 4 thousand 233 new infections of covid-19