Scientists have invented a super drug that keeps coronavirus out of the cell

Experts have learned how to use antibodies in the fight against the new coronavirus. A new effective tool was presented by scientists from the University of Washington.

The researchers reportedly created the drug from a mixture of antibodies obtained from recovered COVID-19 patients. The substance, as it were, locks the cells of the body, preventing a harmful virus from entering them.

The authoritative journal Science says that the drug effectively recognizes and blocks the mechanism of infection with coronavirus and prevents it from entering cells.

The principle of action of antibodies is as follows: one of the molecules blocks the interaction of proteins on the surface of the virus with the receptors of the cells of the body, and also turns off the mechanism of infection, preventing the coronavirus from merging with the cell membrane.

Tests carried out on experimental animals have shown that low doses of S2E12 and S2M11 antibodies protect against infection by preventing the virus from replicating in the lungs.

In addition, their combination does not allow the appearance and multiplication of mutant forms of the virus. This is an additional advantage of the drug, as it protects against the possible development of resistance of the virus to certain substances.

Earlier, American scientists named a vitamin that reduces the risk of death from COVID-19. After a series of studies, it turned out that among patients with coronavirus with sufficient levels of vitamin D in the blood, there are an order of magnitude fewer severe cases than among those who are deficient.

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Scientists have invented a super drug that keeps coronavirus out of the cell

Experts have learned how to use antibodies in the fight against the new coronavirus. A new effective tool was presented by scientists from the University of Washington.

The researchers reportedly created the drug from a mixture of antibodies obtained from recovered COVID-19 patients. The substance, as it were, locks the cells of the body, preventing a harmful virus from entering them.

The authoritative journal Science says that the drug effectively recognizes and blocks the mechanism of infection with coronavirus and prevents it from entering cells.

The principle of action of antibodies is as follows: one of the molecules blocks the interaction of proteins on the surface of the virus with the receptors of the cells of the body, and also turns off the mechanism of infection, preventing the coronavirus from merging with the cell membrane.

Tests carried out on experimental animals have shown that low doses of S2E12 and S2M11 antibodies protect against infection by preventing the virus from replicating in the lungs.

In addition, their combination does not allow the appearance and multiplication of mutant forms of the virus. This is an additional advantage of the drug, as it protects against the possible development of resistance of the virus to certain substances.

Earlier, American scientists named a vitamin that reduces the risk of death from COVID-19. After a series of studies, it turned out that among patients with coronavirus with sufficient levels of vitamin D in the blood, there are an order of magnitude fewer severe cases than among those who are deficient.

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American scientists warned of another dire consequences of coronavirus

Specialists at Yale University in the United States are sounding the alarm. Their research has shown that infection with the new coronavirus can have another dire consequences for the body.

Scientists have proven that the SARS-CoV-2 coronavirus can have a devastating effect on the brains of patients, writes The Independent.

The infection was reported to have been found in the brain of a person who died from COVID-19, in the central nervous system of laboratory mice infected with the coronavirus, and in organoids – three-dimensional cultures of neurons that mimic the brain.

It is noted that the new coronavirus causes a silent infection that does not provoke an immune response and restricts access to oxygen for neurons. As a result, both neurons and synapses die, harming cognitive abilities.

According to scientists, the virus enters the brain cells through the ACE2 receptor located on the surface of the cell membrane. However, it is not yet clear how exactly the virus can enter the brain. Presumably, he can do this through the olfactory bulb, eyes, or even the circulatory system.

Earlier, biologists from Uppsala University in Sweden said that they were able to unravel the biological mechanism of increasing blood clotting and the appearance of thrombosis in COVID-19.

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We will not return to classes until it is safe – Televisa News

Esteban Moctezuma, Secretary of Public Education, said Wednesday that he will not return to classes until it is safe for boys and girls, as well as for the school community.

“We will not return to classes until it is safe for our girls and boys (…) we will open with a green light. The 2019-2020 school year is assured, ”he explained in the morning conference of President Andrés Manuel López Obrador.

The Government of Mexico presented this morning the plan to return to activities once the National Sana Distance Day ends on June 1.

It was announced that to locate the level of infections by zones there will be a traffic light made up of 4 colors; red orange, yellow, and green, with five categories.

The green color of the traffic light will be when there are no more restrictions following public safety and health measures, and school activities are reactivated, it was explained.

Esteban Moctezuma added that “when appropriate, we will close the cycle with a face-to-face stage of evaluation, diagnosis and planning of an effort to remedy for the next school year.”

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“Goodbye, Switzerland!”: The next world hockey championship will be held in Minsk and Riga – Komsomolskaya Pravda Radio

  1. “Goodbye, Switzerland!”: The next world hockey championship will be held in Minsk and Riga. Komsomolskaya Pravda Radio
  2. Ice hockey World Cup 2021 in Minsk and Riga may be rescheduled for other dates Sputnik Latvia
  3. IIHF considers postponement of the World Cup 2021 two weeks ahead Hockey on AllHockey.Ru
  4. The 2021 World Hockey Championship will be held in Minsk and Riga, Switzerland declined Weekly Arguments and Facts in Belarus
  5. The next hockey World Cup went to Riga and Minsk: Switzerland will not “butt” Sputnik Latvia
  6. View in the Google News app

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There will be no repression to stop coronavirus – Noticieros Televisa

President Andrés Manuel López Obrador highlighted on Tuesday the commitment of Mexicans to abide by the recommendations of the health authorities and prevent the spread of the COVID-19 coronavirus in the country, for which he reaffirmed that his government will not promote restrictive actions, such as touches of remains.

We recommend you: AMLO government will convene 337 specialists for coronavirus

“That is why, as I wrote yesterday on my Face, democracy yes, authoritarianism, no,” said the federal president during his press conference on Tuesday from the National Palace.

López Obrador emphasized that Mexico has the medical supplies and specialists that are required to face the pandemic and trusted that the country will come out ahead of this emergency.

However, the President of the Republic made a call not to relax the social distancing and thereby encourage the intensity of transmission of the infection to worsen.

With information from Notimex

AAE

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fears of an upcoming health crisis

The panic caused by the Covid-19 pandemic led to the suspension of vaccination campaigns against measles, yellow fever or polio. And the desertification of health centers raises fears of a resurgence of other diseases such as dengue. Some organizations are alarmed by an unprecedented health crisis to come in poor countries.

Choose between plague and cholera “: This is how Seth Berkley, the head of Gavi (Global Alliance for vaccines and immunization), describes the dilemma facing the organization. On March 24, the GPEI (Global Polio Eradication Initiative) recommended the suspension of all marketing campaigns vaccination against polio underway in Africa so as not to promote spread of SARS-CoV-2 virus. While recognizing that this will lead to more paralyzed children and the re-emergence of the disease in countries where it had been eradicated. Afghanistan and Pakistan, where the virus, could be the first victims.

Yellow fever, diphtheria, measles: all vaccination campaigns suspended

And polio is unfortunately not the only one concerned. On March 26, the World Health Organization (WHO) also advocated a “temporary suspension” of vaccination against all other diseases, such as yellow fever, the diphtheria where the measles. WHO considers that the social distancing necessary to contain the Covid-19 is incompatible with the distribution of vaccines in the villages. Some 13.5 million children have already missed immunization against polio, measles, cholera or the meningitis since the start of the suspension, laments Seth Berkley in the magazine Science.

A dengue epidemic in Latin America

In Latin America, it’s a formidable epidemic of dengue who worries. The region already had a sad record in 2019, with more than 3.14 million people infected, an increase of 30% compared to 2015. Since the beginning of the year, more than 661,000 cases have already been confirmed in America from the South including 1,820 serious. While rapid access to medical care generally lowers the death rate below 1%, the overload of health systems due to Covid-19 could cause the number of deaths to explode. Especially since the two diseases present symptoms similar (fever, headache, body aches…). In Guadeloupe, where 7,260 cases have been recorded since October 2019, the dengue Fortunately, it seems to be declining, but the drop in figures could be due to the desertification medical offices since confinement, warns newspaper France West Indies.

The worst measles epidemic since the invention of the vaccine

Measles vaccination campaigns have already been postponed in 24 countries and others planned for later in 2020 in 13 countries are also likely not to take place, warns the United Nations Children’s Fund (UNICEF) . More than 117 million children could be without a vaccine, the organization warns. In the Democratic Republic of Congo (DRC), the measles epidemic is however particularly virulent this year. Since early 2019, the disease has infected 341,000 people and caused 6,400 deaths, three times more than Ebola during the same period. And the disease, 10 times more contagious than Covid-19, spreads like wildfire. According to WHO experts, this epidemic could be ” the worst ever recorded in a country since the invention of the vaccine in 1963 “Reports Nature.

The DRC is not the only country affected. In 2018, 10 million people were affected worldwide, resulting in 140,000 deaths, an increase of 58% compared to 2016. A upsurge linked in large part by reluctance towards vaccination in rich countries, but also to deficiencies in health systems in developing countries. However, the latter are particularly vulnerable. While the measles mortality rate is usually 3 to 6% (already almost 10 times higher than that of Covid-19), it can reach 30% in some regions due to malnutrition and deficiencies in vitamin a. Worse, we recently discovered that measles “destroyed the immune system”, thus leaving the door open to other diseases … like Covid-19.

A vaccine shortage linked to the closing of borders?

WHO recommends, however, the continuation of vaccination in health centers and hospitals. But as is the case in France, we see that in Africa the inhabitants fear to go to these centers for fear of being infected with it. coronavirus. Another problem is the possible shortage of vaccine fueled by the closure of the borders. While it does not yet exist no vaccine against Covid-19, all these diseases are however easily preventable. In the general panic caused by the pandemic of coronavirus, does one measure the scale of risk that one poses on vulnerable populations?

What you must remember

  • To avoid the risk of spreading Covid-19, WHO has recommended temporary suspension of vaccination against all other diseases.
  • Polio and measles are out of control in many countries, however.
  • An upsurge is to be feared, with the key to millions of potential deaths.

Vaccinations: let’s not let our guard down!

Destination Santé article published on 02/28/2010

In just over a century, vaccines will have saved hundreds of millions of lives. They also helped eradicate a disease – the smallpox – and considerably reduce the poliomyelitis. But some, like measles, still resist, often because the number of vaccinations remains too low.

The WHO smallpox campaign from 1967 to 1977 completely eliminated smallpox. In the 1960s, it threatened more than 60% of the world’s population, and one in four people died from it. The situation for polio is different. Although eradication is not yet in sight, the number of infections has fallen by 99% since 1988. In total, more than 5 million people have thus escaped paralysis or death.

In 2008, 106 million children were vaccinated worldwide. A record! Each year, vaccines prevent 3 million deaths and protect 750,000 children from sequelae infectious diseases.

Tetanus, poliomyelitis, diphtheria … these diseases have practically disappeared in France. So why continue to vaccinate? Because virus and bacteria still circulate with us, as in the rest of the world naturally. Vaccination is therefore often the only way to guarantee effective protection.

Vaccination: an altruistic gesture

Protection is for oneself but it is also an altruistic gesture since it contributes to the protection of an entire population. In fact, the more children who are vaccinated, the less they transmit the virus or the bacteria concerned and the more this disease is likely to disappear.

The proof with measles, which France fails to eradicate. Why ? Because children and young adults are too little vaccinated. In 2008, more than 600 cases of measles were declared – 604 very precisely -, 94% of them in people who were not fully vaccinated or … not at all. Between January and August 2009, the number of cases increased further: 1,200 reports and two deaths. This is why it is extremely important to vaccinate infants (in two doses) against measles with the trivalent vaccine, but also to supplement the vaccination of children and adolescents who have received only one dose.

How it works ? During a vaccination, a microbe where are you attenuated, therefore harmless. The organization recognizes it, however, as if it were active and produces antibody to defend. Our defenses will then remember the traces of this battle. So as soon as the germ will come up again, they will react more quickly – and efficiently – to make specific antibodies.

Conversely, without vaccination our immune defenses will not have time to make enough antibodies. Thus virus and microbe will cause a clinical form of the disease, sometimes with serious complications. To build a sufficient defense, several doses are generally necessary. This is the purpose of reminders, which consolidate and maintain immune memory. Like all medicines, vaccines can cause side effects in some people. They are most often moderate and transient – fever or localized reactions such as redness, pain or swelling. Allergic reactions are certainly possible, but it is exceptional that they have a character of gravity.

This will also interest you

The major pandemics of the 20th and 21st centuries In this video, go back in time to discover the pandemics that have marked our history over the past hundred years. Influenza viruses, Ebola, or even HIV, they have infected the whole world.

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tennis player published a phone number for communication with fans

In this difficult time, the main thing is to support each other in all available ways.

Russian tennis player Maria Sharapova, who lives abroad, decided to support her fans during quarantine and self-isolation.

In her Instagram, Sharapova published a phone number for communicating with fans. She promised that she would respond to subscribers through text messages.

Sharapova urged people to share their recipes, as well as tell what they do in quarantine. You can also ask a question or just say hi to the tennis player.

Maria noted that so far her number is available only to subscribers from Canada and the United States, but soon he can earn in other countries.

Sharapova

Sensational statement made Sharapova in February in her own column for Vanity Fair. She announced that she was completing a sports career. The reason for this was numerous injuries.

In Mary’s personal life, things are much better. Fans of the tennis player managed to expose the engagement of Sharapova with Alexander Gilks.

April 04, 2020
18:07

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Wimbledon tournament canceled for the first time since 1945

The prestigious tournament has been rescheduled for next year.

The prestigious Wimbledon Grand Slam tennis tournament was canceled due to a coronavirus infection pandemic. It was supposed to take place in the UK from June 29 to July 12.

By the decision of the organizers, the 134th championship will be held from June 28 to July 11, 2021.

True, this is not the first canceled Grand Slam tournament. At the beginning of the year, the starting one out of four took place in Australia, but the second – the French Open, scheduled for May-June, was also canceled.

Now the oldest tennis tournament has broken – Wimbledon, which has been held in England since 1877. It was canceled only in 1945, when the competition was not held due to the Second World War.

The tournament organizers noted that they were primarily guided by the health and safety concerns of all those who would come to the championship: players, guests, participants, employees and volunteers, according to an official Wimbledon website.

Among Russian athletes at Wimbledon, only Maria Sharapova won in singles – in 2004. Vera Zvonareva, Olga Morozova, Alexander Meterveli played in the finals.

April 01, 2020
19:01

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What chronic diseases are especially dangerous during the time of coronavirus | World Events – Estimates and Predictions from Germany and Europe | DW

SARS-CoV-2 coronavirus epidemic continues to spread worldwide – the total number of deaths from pneumonia COVID-19 exceeded 42,000. Entire countries are quarantined, epidemiologists and virologists do not cease to call for self-isolation of those at risk: people over 65 years and patients with chronic diseases and immunocompromised. Who needs to be especially careful, and what diseases lead to malfunctions in the immune system?

Asthma and chronic lung diseases

Bronchial asthma is a chronic disease that is characterized by repeated attacks of suffocation and breathing with a whistle. The frequency of seizures can vary from several times a day to several times a week. WHO estimates that asthma affects 235 million people worldwide. It is also the most common chronic disease in children.

During an asthma attack, the mucous membrane of the bronchi swells, the airways spasm and narrow, resulting in less air entering the lungs. It becomes difficult for asthmatics to inhale and especially exhale. Attacks are accompanied by cough, wheezing, increased shortness of breath. The body is struggling to counteract them, and this struggle significantly weakens it.

Girl uses an inhaler

WHO estimates 235 million people suffer from asthma

Asthma attacks can trigger allergens and respiratory infections. In this case, the immune system has to fight not only with asthma, but also with other diseases. Sometimes she is unable to cope with her task, and in the most adverse cases, this can lead to irreversible consequences.

Another disease of the respiratory system is chronic obstructive pulmonary disease (COPD). It is believed that one of the main causes of COPD is tobacco smoke, while both active and passive smokers are at risk. The immune system of people with COPD, which also has to fight other diseases, is experiencing a double burden. The lungs of patients with COPD are severely damaged, and viruses have far fewer barriers to entry.

Diabetes

Diabetes occurs when the pancreas does not produce enough insulin or when the body cannot use the produced insulin effectively. This leads to a chronic increased blood sugar – hyperglycemia.

Two types of diabetes are known. The first type, which is also called insulin-dependent, is characterized by a lack of insulin production. It affects mainly children. Type 2 diabetes affects about 90 percent of those who have the disease. It develops as a result of the fact that the body is unable to effectively use the produced insulin.

The doctor is holding an ampoule with insulin

About 90 percent of patients with this disease suffer from type 2 diabetes.

Elevated blood sugar weakens the body’s resistance. Infectious diseases, especially those accompanied by fever, can dramatically worsen the condition of diabetics – even those whose disease is well controlled with drugs.

But with diabetes, not only carbohydrate metabolism is disturbed. The disease can affect the blood vessels and affect the condition of the internal organs, exposing them to additional loads. And then the immune system becomes much more difficult to protect the body from alien and harmful interference.

Cordiallyvascular disease

More people die from cardiovascular disease (CVD) each year than from any other disease. According to the WHO, in 2016 they caused the death of almost 18 million people, this is a third of all deaths in the world. In 85 percent, death came from a heart attack (heart attack) or stroke. CVD includes coronary heart disease, in which blood vessels are not able to supply blood to the heart muscle, and vascular disease that supplies blood to the brain.

Any infectious disease for people with similar problems can be fatal. The same applies to those who suffer from disorders of the heart valves: viral infections can destabilize the work of the whole organism.

Hypertonic disease

Hypertension or hypertension, characterized by high blood pressure, is a common disease. In Germany alone, there are 20-30 million hypertensive patients, and their number in the world is 1.13 billion.

The doctor measures the pressure of a woman

In Germany alone, 20-30 million hypertensive patients

Hypertension is considered one of the main causes of death on our planet. It also increases the risk of developing diseases of the cardiovascular system, brain and other diseases.

High blood pressure leads to damage to arterial vessels and affects the functioning of the heart, which is forced to be in an overload condition. This can lead to the development of severe cardiovascular diseases and, as a result, weaken the body’s resistance to viruses and other infections.

Oncological diseases

Patients with cancer are also at risk. Cancer is the second leading cause of death in the world. According to the WHO, in 2018, 9.6 million people died from them.

Cancer cell division under the microscope

Cancer cell division

One of the most common treatments for oncology is chemotherapy. In this case, cytostatics are used – antitumor drugs that disrupt the processes of growth, development and division of malignant cells. But cytostatics attack not only cancer cells – healthy tissues also suffer from them, it damages the immune system, and the body becomes more susceptible to pathogenic microorganisms.

The degree of detrimental effect on immunity in the treatment of cancer depends on various factors, including the type of cancer and the general condition of the patient. In any case, people undergoing chemotherapy or radiation should be extremely careful. Even a relatively harmless cold can become extremely dangerous for them, therefore, during an exacerbation of respiratory diseases, cancer patients should, if possible, avoid contact with those who cough and sneeze.

Autoimmune diseases

Autoimmune diseases increase the risk of infection not only with coronavirus, but also with other infections. They occur when, for an unknown reason, a failure occurs in the immune system and it begins to attack not alien viruses and pathogens, but tissues and internal organs of its own body. There are many autoimmune diseases – among them there are rare and more common, such as rheumatoid arthritis, psoriasis, multiple sclerosis or Crohn’s disease (chronic inflammation of the intestine).

For patients suffering from autoimmune diseases, doctors prescribe immunosuppressants that suppress the activity of the immune system. Immunosuppressants and people with HIV are taking. The defense mechanisms of a weakened immune system fail, and the body becomes an easy victim of infections. Therefore, those who are forced to take immunosuppressive drugs should be extremely careful.

And finally, do not forget that some pathogens of infectious diseases are also dangerous for people without any chronic diseases. Therefore, everyone, without exception, should be careful and not neglect the rules of hygiene.

See also:

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