AstraZeneca vaccine “amazing” – low dose works better than high dose

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AstraZeneca vaccine “amazing” – low dose works better than high dose

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The preparations for the mass vaccinations are in full swing

With the British-Swedish pharmaceutical company Astra Zeneca, another company has presented positive data on a corona vaccine relevant for Europe. Thousands of people are to be vaccinated every day as early as the end of December, but no later than the beginning of next year.

With the British-Swedish pharmaceutical company AstraZeneca, another company has presented positive data on a corona vaccine relevant for Europe. The effectiveness is less than that of the competition – but one detail amazes the study leaders.

Mhe British-Swedish pharmaceutical company AstraZeneca has presented another company with positive data on a corona vaccine. The vaccine avoids with an average of 70 percent probability of contracting Covid-19, the company announced on the basis of data from the important test phase III.

Andrew Pollard from the research team said they were very satisfied with the high effectiveness of the vaccine candidate. The number even increased to more than 90 percent if the subjects were given half a dose and then a whole instead of two full doses.

The effectiveness is based on interim results of clinical studies in the UK and Brazil. When an initial half dose was given and another full one month later, the effectiveness was 90 percent – with two full doses, however, only 62 percent. If you combine these values, you get around 70 percent, according to AstraZeneca. In those who received the vaccine in the study, there was not a single severe disease course after infection. Of 11,636 test subjects, 131 tested positive for Covid-19 during the study.

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Pollard rated the study results as “amazing”. With a view to the result that the vaccine offers higher protection at a lower dose, more work is needed, Pollard told the BBC on Monday. “I think this is a really exciting and baffling result that we need to look into further.” AstraZeneca boss Pascal Soriot said the lower dosage was a huge benefit as it would allow more people to be vaccinated faster.

British Prime Minister Boris Johnson welcomed the announcement that the vaccine could achieve up to 90 percent effectiveness as “fantastic” news. “Incredibly exciting news that studies have shown the Oxford vaccine to be so effective,” said Johnson Twitter. “There are more security checks to be made, but these are fantastic results.”

According to preliminary data, the effectiveness of the vaccines from Pfizer / Biontech and Moderna is around 95 percent for double vaccinations. The AstraZeneca vaccine can be stored according to the information at refrigerator temperatures of two to eight degrees.

EU has ordered 300 million cans

The AstraZeneca active ingredient developed jointly with the University of Oxford has long been one of the most promising candidates: the EU had already ordered up to 300 million doses of it in advance. In total, various countries have already ordered billions of cans from AstraZeneca.

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The active ingredient AZD1222 is based on the weakened version of a chimpanzee cold virus. It contains genetic material from a surface protein with which the Sars-CoV-2 pathogen docks onto human cells. The agent works in two ways: It is supposed to promote the formation of specific antibodies as well as T cells – both are important for the immune system. Unlike the vaccines from the Mainz company Biontech and the pharmaceutical company Pfizer as well as the US company Moderna, the British-Swedish preparation does not belong to the mRNA vaccines.

The Oxford researchers recently reported in the specialist magazine “The Lancet” that their vaccine was also effective in the elderly in clinical phase II tests. In the phase II study, participants both under and over 56 years of age had good immune responses, the team wrote. The vaccine was even better tolerated by the elderly than by the younger ones. According to the information, around 240 of the 560 healthy study participants were over 70 years old. Older people have an increased risk of a severe course of Covid-19.


Brazil: Bolsonaro was rebuked and insulted in the …

The president of Brazil, Jair Bolsonaro, was rebuked in the streets of the city of Macapa, located in the northeast of the country, after criticizing the demonstrations for racial equality in his speech at the G20.

In a video broadcast on social networks and published by the newspaper Folha, it is seen how Bolsonaro walks yesterday through the streets of the city with the body out of the window of a car, while people on the street repeatedly yell “out” and pronounce insults directed at both him and his entourage.

The repudiation of the president occurred in Macapá, a city that has been suffering the effects of an electrical blackout for 19 days after a fire burned down an energy substation.

This Friday, the president of Brazil had published a series of critical tweets against protesters who, on Black Awareness Day, spoke out for racial equality. In addition, Vice President Hamilton Mourao denied in statements to the press that there was racism in Brazil.

“Those who incite the people to discord, fabricating and promoting conflicts, attack not only the nation, but our own history. Whoever preaches this is in the wrong place. Its place is in the trash!“, expressed Bolsonaro in social networks.

The controversy has crossed the country’s borders because Bolsonaro has said in his speech at the G20 that there are people who “want to destroy” the image of Brazil’s diverse culture in the world.

“It was the essence of this people that won the sympathy of the world. However, there are those who want to destroy it and put in its place conflict, resentment, hatred and division between races, always masked as’ struggle for equality ‘or’ social justice ‘”. remarked.

General repudiation

Bolsonaro’s image also suffered after the death of José Alberto Silveira Freitas, a 40-year-old black man, who was beaten to death at the hands of two custodians of a supermarket in the city of Porto Alegre. That Thursday a wave of protests broke out in several Brazilian cities.

Freitas died after being hit for four minutes by two security guards from a store. In a video recorded by a witness, you can see how a guard holds him so that another can beat him.

The action aroused a general repudiation in Brazilian society, since it also took place a few days before the Racial Awareness Day in which demonstrations are traditionally held.

The Brazilian president is not going through his best moment after the vast majority of the candidates backed by him were defeated in the first round or did not start as favorites in the second of the municipal elections that will be decided next Sunday.


Brazil attributes recommendation of social distancing to human error

The Ministry of Health of the Government of Jair Bolsonaro attributed the publication to a “human error” of a message on his social networks in which he recommended social distancing as a measure to prevent the spread of the new coronavirus.

The Ministry published a message this Wednesday in which defended social distancing as the best measure to stop the advance of covid-19 in the absence of remedies to prevent or treat the disease, but shortly after he deleted it without explanation.

“Our biggest action against the virus is social distancing and adherence to individual protection measures,” said the message that the Ministry later described as wrong information.

The message caused surprise because Bolsonaro’s government is one of the most skeptical about the severity of the pandemic and has criticized the social distancing measures imposed by regional and municipal administrations to combat covid-19.

The far-right leader alleges that the measures will not stop the pandemic but they can generate a generalized bankruptcy of companies and massive layoffs of employees, and that hunger can cause more deaths than the disease itself.

In a statement last week in which he referred to the possibility that regional governments again impose social distancing measures in the face of a possible second wave of the pandemic, Bolsonaro affirmed that Brazil cannot be “a country of queers.”

After several hours of silence on the reason for having deleted the message that recommended social distancing, the Ministry of Health clarified in a statement that the publication was withdrawn from social networks and later corrected “for containing wrong information: a human error that already was corrected. “

Ministry contradicted Bolsonaro

In the initial publication the Ministry stated that there are no remedies in the world to prevent or cure covid-19 despite the fact that Bolsonaro, who contracted the disease, defends the use of chloroquine to treat the new coronavirus.

The head of state assures that he overcame the disease with chloroquine, an antimalarial whose effectiveness to treat covid is not scientifically proven and that is not recommended due to its side effects, including cardiac arrhythmias.

In the message that “corrected” the initial information, the Ministry admitted, however, that there is still no “effective solution” to serve the population and avoid the risk of contagion.

In his new message, he only recommends as preventive measures “until an effective solution is found” the use of alcohol gel and masks, as well as frequent hand washing.

“The treatment protocol for the disease and the use of medicines is at the discretion of health professionals, in accordance with the will of the patients,” says the corrected message.

The denial of the Ministry of Health to social distancing as a measure to prevent coronavirus It was announced on the same day that Brazil registered 34,091 new cases of covid-19, bringing the total number of infections closer to 6 million, amid an acceleration in the transmission curve after several months down.

According to the bulletin released this Thursday by the Ministry of Health, Brazil registered 756 new deaths from the coronavirus in the last 24 hourss, so the accumulated number of deaths reaches 167,455.

These figures confirm Brazil as the second country with the most deaths in the world from covid, after the United States, and as the third with the most cases, after the United States and India.


Central American hurricanes push up Arabica prices

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Hurricanes follow one another in Central America. The last, Iota, dislodged hundreds of thousands of people in the countries of the American isthmus. In Honduras, the region’s leading exporter, damage to coffee plantations is worsening, pushing up arabica prices.

An assessment of the damage caused by Hurricane Iota to Honduran coffee plantations this week has yet to be completed. We will have to wait until next week. And we will not know the results of this inspection until the end of November or early December.

Already 90,000 bags lost with the first hurricane

But the damage will accumulate after a first hurricane, And, two weeks ago, which had already caused the loss of 90,000 bags of beans according to the Honduran Coffee Institute.

Honduras is the region’s leading exporter and the world’s fourth largest exporter, with around 6 million bags shipped per year. But Guatemala, world number 6, is also affected, as well as Nicaragua. Harvesting, drying and shipping can be very difficult.

Prices have recovered 30% since the low in June

Hence the concern that manifests itself on the New York Stock Exchange where this variety is listed. The Arabica pound topped $ 1 24, its highest level in two months. This is an acceleration of the uptrend that we have already observed since the low in June, when the Arabica had fallen below a dollar a pound, because of the closure, linked to Covid-19, cafes and restaurants. Since then, arabica has regained 30%.

Hurricanes, rust, Niña: the hazards on the supply are increasing

Because the threats to arabica production are increasing. Central America is hit by hurricanes but also by an upsurge in rust, a disease of coffee, which developed when prices were very low, coffee farmers had less income to maintain the trees. Finally, drought is raging again in the coffee plantations of Brazil, this time a consequence of the return of La Niña. The flowers of the coffee trees wither prematurely, which does not bode well for the next harvest.

Rebound in demand in the second half of 2021?

Brazil is the world’s leading producer and exporter of coffee, and particularly plain arabica, a lower quality than Central American arabica, but which weighs very heavily in volume. However, according to Goldman Sachs, global coffee demand should pick up again in the second half of 2021, with the expected reopening of hotels, cafes and restaurants around the world.


Vatican: The Pope’s economic summit relies on the Greta strategy

AThe digital conference “Francesco’s Economy” began on Thursday afternoon as a mixture of World Church Day, youth service and economic summit. The event, which is attended by more than 2000 young people from 120 countries as well as internationally recognized economic experts, is intended to provide new impulses for a new, sustainable and fairer world economy.

At the start of the conference, the moderators from Assisi, Italy, switched to participants in Sri Lanka, Croatia, Congo, Mexico and, of course, Rome, who sent happy and excited greetings to the world between musical interludes. Technically, the start went as smoothly as possible and was able to illustrate the diversity and global scope of the event, which will continue up to and including Saturday and will be broadcast live.

The comment field on the associated website was also quickly filled with expectant messages. Lucas from Brazil commented: “Hello everyone! I’m in Brazil and ready to build an economy that works for everyone – not just the richest 1%! ”

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It is precisely this hope that Pope Francis inspires for “Francesco’s Economy”, to which he invited “young economists and entrepreneurs from all over the world” in a letter about two years ago. The head of the Catholic Church wanted to meet those “who are now in their formation and are studying and practicing a different economy”. An economy “that creates life and does not kill, that is inclusive and not exclusive, (…) that cares about what is created and does not plunder it”.

This criticism of the existing economic system is not news from Francis’ pen: As early as 2013, he assumed that this economy would kill. Most recently, in the encyclical “Fratelli tutti” published at the beginning of October, the Pope sharply criticized the market economy and advocated a more solidary society. Subsequently, he was accused of having written the impression that capitalism was the work of the devil, which was incompatible with Christian ethics.

Greta Thunberg also uses simple demands

In Germany, the encyclical was criticized, among others, by Clemens Fuest, head of the Ifo Institute, who was disappointed by the economic aspects of the font. Fuest: “The weather against the markets and alleged neoliberalism is the greatest weakness of the Pope” and criticized the fact that Francis’ statement that globalization had not used the weak and only made them dependent, was “a simple untruth”.

The theologian and economist Andre Habisch criticizes the fact that the economic opponents of the Pope in Germany fail to recognize the role of church social ethics in the struggle for a future worth living in. “Francis’ contribution is to formulate guiding principles and to establish related spaces of thought: this is exactly where the ‘Economy of Francesco’ Festival comes in.”

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Fight for climate protection

Such impulses did not contain any detailed blueprints for a new economic order. Rather, they suggest – like a vision in companies – a direction in which activities and initiatives should move. At the festival, demands may therefore be made that appear naive to the experts, says Habisch.

But: “Even Greta Thunberg’s demands sometimes seem very simple, but she still managed to initiate social discussions about the way we want to live tomorrow.”

These fundamental discussions were held at “Francesco’s Economy” by the young entrepreneurs, scientists and changemakers between the ages of 20 and 35 who were selected by the Vatican and divided into twelve working groups. The so-called themed villages were instructed by scientists and have titles such as “Finances and Humanity”, “Work and Care”, “Energy and Poverty” or “Management and Gift”.

Since the corona crisis prevented a face-to-face conference in March, the participants have since met in monthly online seminars, the results of which they will present until Saturday.

The start was made on Thursday afternoon by the US star economist Jeffrey Sachs, who responded to the suggestions of one of the working groups in a live discussion. The young participants suggested to Sachs, the director of the UN Sustainable Development Solutions Network, to establish a “Child Flourishing Index”.

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An index that scientifically records child welfare and makes it mappable. Sachs supported the proposal and said that it was important for governments to be able to take other values ​​into account in their decisions than just classic economic indicators such as stock market developments.

By the time Pope Francis ends the event on Saturday, other prominent economists such as the Nobel laureate in economics, Muhammad Yunus from Bangladesh, who is considered the banker of the poor, and the Indian physicist Vandana Shiva, who is world-famous as a critic of globalization, will step onto the digital stage.

There will be no final paper. But the organizers hope that the end of the conference will be the starting signal for a global movement that works for a fairer, sustainable economic order. Luigino Bruni, economics professor at the Roman LUMSA University and scientific director of the conference, is convinced that this has already been achieved through the meetings of the past months: “Thanks to Pope Francis, the largest movement of young economists has emerged on the international level,” he said.

Combining social entrepreneurship and profits

The Vatican hopes that the participants will take with them the ideas for an alternative world economy that they have learned about over the past nine months and implement them in their fields.

Jan Pleis, industrial engineer from Leer in East Frisia, is one of the German participants and is convinced that the Pope’s plan will work. “The event is the ideal platform for exchanging ideas on an international level.” Pleis, who works at VW and is also building a start-up network in the German-Dutch border region, took part in the “Energy and Poverty” group.

On a monthly basis, he met with the other participants from Brazil, Italy, Argentina, Mexico, Great Britain and France, for example. As an example of how the “Economy of Francesco” actually works, he mentions the Swedish start-up Trine, which was presented at one of the online seminars.

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Trine enables investments in the production of solar energy in developing countries and promises attractive profits. With the money invested, the company is helping to bring electricity to areas that previously had no access to it.

“This approach was completely new to me, but now not only I know it, but also everyone else in our work group and can use it as a reference point and idea for new projects in the future,” says Pleis. There are many companies around the world like Trine that combine social entrepreneurship and profit and need to be made better known, said Pleis. “The ‘Economy of Francesco’ is a perfect starting point and multiplier for this.”

In addition to the professional organization, Pleis, who is himself a Protestant, liked the fact that the Catholic faith did not play a central role. “We were not indoctrinated, otherwise I would have got out again.” But the opposite was the case: “Many people who belong to other religions took part.”


Despite Bolsonaro, the first …

Brazil received this Thursday the first batch with 120,000 doses of CoronaVac vaccine, developed by the Chinese laboratory Sinovac Biotech, as announced by the Government of San Pablo. “It is a very important milestone,” state governor Joao Doria underlined from the Sao Paulo airport.

The vaccine arrived in Brazil through an agreement with the Butantan Institute, attached to the Government of São Paulo, and became the subject of a dispute between President Jair Bolsonaro and Doria, his former ally and current political rival.

The confrontation increased in intensity last week, when the national health surveillance agency (Anvisa) suspended the trial on volunteers in Brazil for 48 hours, arguing “a serious incident” occurred during testing.

Bolsonaro celebrated the stoppage of the study on social media, and the regional authorities of São Paulo, as well as the directive of the Butantan Institute, expressed “outrage” and guaranteed that the incident was not related to the investigational drug.

What motivated the suspension of the tests was the suicide of a volunteer participating in the trial, but Anvisa immediately authorized that they be retaken. After the episode, the health authority explained that suspensions in this study phase are common and that “does not necessarily mean that the product under investigation is not of quality, safe or effective.”

Sinovac’s vaccine

The agreement between Sinovac and the Butantan Institute contemplates the shipment of a total of 6 million doses by the end of the year, as well as the delivery of raw material to manufacture another 40 million doses in São Paulo, according to the regional government. Anvisa authorization is necessary for the application of the vaccine in Brazil.

CoronaVac is one of the most advanced vaccines in the world, in close proximity to the US pharmaceutical giant Pfizer, who presented interim Phase 3 results showing “more than 90%” efficacy.

Sinovac’s vaccine is also in phase 3 of human trials, the last stage before its homologation, which involves thousands of volunteers in Brazil, Indonesia and Turkey.

China authorized the administration of experimental vaccines for “urgent” cases in July. At least hundreds of thousands of Chinese have already received the vaccine from Sinovac or those from the public Sinopharm laboratory.

Brazil, with 211 million inhabitants, has more than 167,000 deaths and almost 6 million infected with the new virus. São Paulo, the most populous state in the country, registers more than 1.1 million cases and almost 41,000 deaths from the disease.


An entire family was crushed to death after the collapse of a cliff in Brazil | Chronicle

An unexpected collapse on the cliff of Pipe, in Rio Grande do Norte, in Brazil, ended the life of a young family, along with their dog, who were resting in the shade when everything collapsed, were left under the rubble and died from injuries.

The tremendous event occurred at noon on Tuesday when Stella Souza (33), Hugo Pereira (32), Sol, your 7 month old baby, and your pet Breeze They came to the beach to spend their non-working day together, despite warnings about the hazards of the cliff. The family was left in its shadow and when it began to collapse, they were trapped.

Those who witnessed the terrible scene tried to save them. When removing the debris, they found the body of the mother, who was holding the baby in an attempt to protect him from the fall. While the little one was still alive, did not resist the wounds and died hours later.

“We dig until we find the father, and then we find the mother and the child. The baby was still breathing. By chance, a doctor was passing by at that time. He tried to revive the baby, but he couldn’t do it anymore “, declared the nautical businessman Igor Caetano, witness to the accident, to site G1.

Stella and Hugo fulfilled their dream less than a year ago of opening their hostel “Morada Brisa” a few meters from the paradisiacal beaches of Pipa, which received about 7 thousand people per day in high summer season.

When the coronavirus pandemic arrived, however, the flow of guests in the couple’s accommodation was disrupted. “We have chosen to protect those who live here and then, with peace of mind and security at the right time, we will return with love”, stated the couple in a post on the hostel’s official site.

Hugo, meanwhile, had become known in Brazil for traveling around the country in a volkswagen combi with his dog in 2016. In one year, they traveled 14 thousand kilometers and visited 15 Brazilian states.

The family was enjoying their day off when the landslide occurred.

The danger of the Pipa cliff

“I was born and raised here and this has always happened, but more and more the sea is destroying the cliff more. We see tourists enjoying the shadow of the cliffs and we ask them to leave because we know the risk ”said a fisherman to the same medium.

According to the municipality of Tibau do Sul, to which Pipa belongs, posters are put up to warn of danger but the tide carries them away.

Faced with the repetitions of the death of the family, the communication secretary of the municipality, Fábio Pinheiro, stated that the victims had been alerted to the risks by a municipal official shortly before the accident.

Hugo and Stella, with their 7-month-old baby.


In Arabic .. Rodrigo sends a message to the Egyptians after participating with the Olympic Brazil against the Pharaohs

The Brazilian Rodrigo Jos, the star of Real Madrid, was keen to send a message to the Egyptian people, after his participation with the Brazilian Olympic team, against the Egyptian Olympic team in a friendly way in Cairo.

Brazil lost the day before yesterday, Tuesday, to Egypt, with two goals to one, as part of the team’s preparations for the Tokyo Olympics, which will be held next year.

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Rodrigo wrote through his official account on the social networking site “Twitter” in Arabic: “I would like to thank you for your kindness, your hospitality, and your respect for me and all my colleagues in Cairo!”

He added, “I follow the participation of all Egyptians and the Arab community on social networks, and I thank you for your messages!”

He concluded: “It is always wonderful to share these moments with everyone! Thank you very much.”


Formation of the friendly Olympic Brazil-Egypt match

Shawky Gharib, coach of the Egyptian Olympic team, announced the formation of the Young Pharaohs for the friendly match against Brazil.

The Egyptian Olympic team previously played a friendly match with its South Korean counterpart and drew 0-0, while the Brazilian team defeated the Korean team 3-1.

The formation of Egypt came as follows:

Goalkeepers: Mahmoud Gad.

Defense line: Karim al-Iraqi – Muhammad Abd al-Salam – Ahmad Ramadan “Beckham” – Mahmoud Marei – Karim Fouad.

Midfield: Akram Tawfiq – Ammar Hamdi – Nasser Maher.

Offensive line: Salah Mohsen- Ahmed Yasser Rayan.

The formation of the Brazil national team came as follows:

Daniel Fozato, Emerson, Lianco, Gabriel, Chau Henrique, Maicon, Wendell, Rainier, David Neres, Rodrigo, Matthias Kona.


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