The Swedish company Fractal Design has released another computer case from the popular Meshify family called Meshify 2 Compact. The novelty continues the tradition of the older Meshify 2 models, but, as the name suggests, is more compact in size.
Meshify 2 Compact is capable of accommodating ATX / microATX / Mini-ITX motherboards. The physical dimensions of the chassis are 424x210x475 mm, and the weight is 7.7–8.1 kg, depending on the type of side panel. By the way, the case is available in five variants, differing in color (white or black), side door made of metal or tempered glass, including its tint.
The body is designed for excellent airflow. This is supported by a mesh front panel, nylon filters, an open interior layout and support for a large number of fans (7x 120mm or 4x 140mm), three of which are branded Dynamic X2 are included in the box. In addition, there is support for SVO radiators with a standard size of 360/280 mm.
Meshify 2 Compact boasts a fully removable top bezel and fan bracket for easy access, support for 169mm CPU coolers, seven expansion cards up to 341mm long (360mm without front fans) and three / six 3.5 / 2.5 drives inch.
Meshify 2 Compact is available overseas with a suggested retail price of $ 100 for Meshify 2 Black Solid, and $ 110 for the rest of the glass side panel versions.
Berlin – An international research team led by structural biologist Andrea Thorn has been trying since the beginning of the pandemic to decipher individual protein components of Sars-CoV-2 as precisely as possible – among other things, so that drug developers around the world can search for remedies. But there is still a lot that remains to be clarified.
Berlin newspaper:Frau Thorn, wWhy is it so important to structurally examine the coronavirus?
Andrea Thorn: The coronavirus is made up of molecules. Understanding their structure exactly and having models of these molecules is necessary in order to find out how Sars-CoV-2 works in the first place: If, for example, the virus takes over a human cell and causes it to produce more viruses, then every single step has been taken made from a protein molecule. And disabling these protein molecules therefore means stopping the infection. But you can only do that if you know it very well: you have to understand the lock in order to be able to build a key. We are improving the molecular models of the coronavirus and making them publicly available online so that drug developers can specifically search for active ingredients that match the proteins and block them, for researchers at universities and also in the pharmaceutical industry.
You head the “Coronavirus Structural Task Force”, an international network of experts in the field of structural biology. How did it come about?
In February 2020 I looked at molecular models of the Sars coronavirus, which had already triggered a pandemic in 2002 and is very similar to the new coronavirus, and found out that more biological knowledge can be extracted from the structures with today’s methods. With this knowledge, I started a month later, together with my work group and international colleagues, to systematically examine the structures from Sars and the new coronavirus. From then on we have grown steadily. Today we’re a pretty diverse group with 27 team members in nine time zones. That was quite unusual for a research project: no professor at the top, at the beginning without research funding – we are now funded by the Federal Ministry of Research – and all results go online immediately. But we were able to use our knowledge to fight the pandemic – and that was the reason we joined forces.
So the pharmaceutical companies don’t need approval from the task force?
No. We want drug developers from the Philippines to Brazil or India, all over the world, to have access to our data.
What does Sars-CoV-2 look like in simple terms?
The coronavirus is not completely round. It’s like a soap bubble in constant motion – wobbly, if you will. The outer layer is thin, soft and made up of fatty acids that are chemically similar to soap. Because of this, soap can completely dissolve the shell of the virus – provided that the hands are washed long enough. The outer layer is covered by so-called spines, which allow the virus to penetrate into lung cells, for example. But what you call a virus – that is actually just the form of transport, the “virion”. Inside, it carries genetic material for a total of 28 protein molecules, most of which are first built in the host cell in order to transform it into a virus production facility.
All this is difficult to imagine for laypeople.
Many people still believe that viruses cannot be made visible. They may even fail to realize that the colored images shown in the media are images of the virus. The virus and its danger are not visible. The people do not see the many dead, they do not see the completely overloaded intensive care units because there is a ban on visits. This is also one of the reasons why we also made and printed a 3D model of the virus so that we can make the danger a bit more tangible.
How do you decipher the molecular structures?
The entire virus is not measured, but individual molecules. Structural biologists are looking for one of the 28 different proteins that make up Sars-CoV-2, for example the spikes on the surface of the virus. The molecule is not dangerous on its own, which makes work a lot easier. Genetically modified bacteria produce many copies of this molecule. Then there are two options: Either we take the thinly applied sample, cool it down to very low temperatures and put it under an electron microscope. A so-called transmission image is created, a negative image of the virus protein. From these individual snapshots of the molecule you can make a three-dimensional picture and use it to build a model of the molecule.
The other option is to crystallize the egg white. The crystals are a tenth of a millimeter in size and consist of thousands of identical protein molecules. This crystal is then measured using X-rays at a so-called synchrotron, a particle accelerator, such as Bessy II in Berlin. These data also make it possible to build a three-dimensional model of the molecule from which the crystal was made.
What role does the task force take on in these research steps?
We review and improve the models that were generated with the measurement data. My team members sit in front of a 3D monitor wearing special glasses and look at every single atom. Sometimes we build the models from scratch. Of course, you don’t just have to orientate yourself on the measurement data, but also position the individual atoms in a chemically sensible way, at the correct distance from one another: It’s a bit like how computers play.
How long do the individual steps take?
The multiplication in the bacterium can take one to 36 months with the purification until it works. The egg whites crystallize in one to 24 months. The measurement in the synchrotron takes about three minutes. The data acquisition and the assembling of the structures with the special glasses take a week to four months.
That means your team is responsible for the 3D modeling of the structures?
I agree. With 10,000 or more atoms per molecule, mistakes can easily happen – especially under the pressure of a global pandemic. These mistakes can doom the development of a drug from the outset. That is why we have to find and fix the errors beforehand. This is also very important for the biological questions about the virus. We are not the pioneers who will measure the structures, nor are we the ones who will find the medicine. We can enable and facilitate it and ensure that everything that is possible is really extracted from the experimental data.
How big are the gaps in knowledge about Sars-CoV-2 today?
A lot has been discovered in the past year. Researchers around the world have worked together – so do we! But of the 28 molecules of the virus, only 17 have so far been successfully measured. And even about these 17 we know we don’t know enough. Its a lot to do.
Is there anything that amazed you in the course of your corona research?
At Sars, people got very sick very quickly and went to the hospital soon after their infection. Once they were hospitalized, they could no longer infect anyone – that is, the outbreak could be more easily contained. With the novel coronavirus, around 15 percent of people develop no or few symptoms, but are still contagious. So the coronavirus is particularly dangerous because it doesn’t make you sick that badly. That sounds paradoxical, but of course it means that many more people can become infected and, in the end, there are many more deaths.
What do you know about the molecular details of virus mutants, new virus variants?
So far there are not many structures – the determination takes a few weeks or months – but these structures can be simulated very easily on the computer, as only a few of the thousand atoms in the molecule change.
What would have happened if scientists hadn’t stopped researching the virus after the Sars pandemic from 2002 to 2004?
The studies never stopped entirely. There were researchers like the Lübeck biochemist Rolf Hilgenfeld, who did corona research for many years in a quiet little room – with one and a half positions and small budgets. We owe the knowledge at the beginning of the corona pandemic to them. But yes, after the Sars pandemic, research declined significantly and was no longer funded as much. With Sars-CoV-2 it becomes clearer than ever: It is worthwhile to invest in research projects in the long term, and indeed for longer than one legislative period. If Sars research had been carried out continuously, we would have had a lot more knowledge about coronaviruses at the beginning of the pandemic. That would have been a huge benefit and I hope we are better prepared for the next pandemic.
HP decided to get serious about the gaming peripherals market. Today the American vendor announced the purchase of HyperX, a subsidiary of Kingston Technology, for $ 425 million. The company is currently awaiting regulatory approval and expects the deal to close in the second quarter of this year.
In a published press release, HP Inc. makes it clear that she is only interested in HyperX gaming peripherals. Kingston will retain “DRAM, flash and SSD products for gamers and enthusiasts.” It is difficult to say for now what will happen to peripherals for console players such as headsets and various accessories. In the PC segment, the HyperX and Omen brands are likely to coexist under HP’s leadership.
Recall that Kingston Technology introduced the HyperX brand back in 2002 with a line of high-performance DDR1 RAM modules. Since then, the product range has been expanded with peripherals for gamers as well as solid state drives in a variety of formats.
Publisher Paradox Interactive announced the postponement of the release of Vampire: The Masquerade – Bloodlines 2. The game will definitely not be released in 2021, and another approximate date was not announced either.
The main reason for the transfer was that Paradox Interactive stopped working with Hardsuit Labs, which created the project. The authors of Blacklight: Retribution have already been replaced by another studio, but its name has not yet been announced.
Paradox Interactive has declared the importance of Bloodlines 2 to them and the gaming community. The publisher was not happy with the result, so it takes more time to develop and completely changes the team. Acceptance of pre-orders for the game has already been stopped. Other details will be announced later.
In the weeks leading up to the official release of the Radeon RX 6700 XT, AMD is finding it increasingly difficult to keep the details of the new graphics card a secret. Information has already appeared on the web that the “reds” will release two versions of the GPU Navi 22 XT, one of which is intended for cards with factory overclocking. According to new leaks, the differences between these video cores lie not only in the frequency potential, but also in the standard TGP level.
The two versions of the AMD Navi 22 XT graphics processor for the Radeon RX 6700 XT video cards are codenamed ASIC A and ASIC B. The first GPU is characterized by a nominal TGP (Total Graphics Power) of around 230 W, and the second is about 189 W. The junior version can be found only in the Radeon RX 6700 XT operating at reference frequencies.
The source also confirmed that the Radeon RX 6700 series graphics cards use GDDR6 memory chips with an effective frequency of 16 GHz. This means that the bandwidth of the video buffer, taking into account the 192-bit bus, will be 384 GB / s. The final performance of the Radeon RX 6700 XT will be 20-25% higher than that of the Radeon RX 5700 XT.
The official debut of the AMD Radeon RX 6700 XT graphics card, according to available data, is scheduled for March 18. The Radeon RX 6700 will be released a month later.
The GeForce RTX 3080 video card with a TGP level of 320 W is hardly the optimal adapter for fanless systems. Despite this, the Chinese company TureMetal still decided to experiment with passive cooling of the pre-top 3D accelerator Nvidia Ampere. For these purposes, the UP10 radiator case was used, which we talked about earlier.
The heart of the test system was the 6-core AMD Ryzen 5 5600X processor, whose nominal TDP is declared at 65 W. We used an ASUS GeForce RTX 3080 TUF Gaming video card with a specially made contact plate, and heat pipes were used to dissipate heat to the aluminum walls of the case. By the way, the recommended price for the TureMetal UP10 case is $ 770.
Power consumption of the computer during testing reached 410 W, while 347 W was consumed by the video card itself. After just four minutes in the Furmark stress test, the GPU temperature reached 87 ° C, and this is taking into account the low temperature (13 ° C) indoors. On the other hand, for TureMetal UP10, the manufacturer claims the ability to dissipate 300 watts of thermal power, so this result is quite predictable.
Those wishing to build a completely silent system based on the GeForce RTX 3080 will have to cut the power consumption and operating frequencies of the video card through utilities like MSI Afterburner.
Blizzcon 2021 will take place this weekend, an online event due to coronavirus restrictions, dubbed BlizzConline. As you know, the event is hosted by Blizzard Entertainment and is dedicated to the universes of Warcraft, StarCraft, Diablo, Hearthstone, Heroes of the Storm and Overwatch.
According to the insider Kaiser499, this year we will have a lot of interesting announcements at the festival. Separately, the remaster of Diablo 2, also known as Diablo 2 Resurrected, stands out. Previously, this person was noted in truthful leaks about Diablo 4 and Overwatch 2, so his words can be trusted.
Blizzard’s schedule also includes The Burning Crusade Expansion for World of Warcraft Classic (originally released in January 2007), Hearthstone CCG expansion, Diablo: Immortal details, new mobile games including Warcraft Pet Battle Game, and new content for Overwatch 2 and Diablo 4.
Samsung, during a speech at the ISSCC 2021 conference, talked about a new type of RAM based on HBM2 multilayer memory, equipped with an integrated AI processor with a theoretical computing power of 1.2 teraflops. This solution is called HBM-PIM and allows smart memory to independently perform operations that are usually reserved for a CPU, GPU, ASIC, or FPGA.
The innovative memory class is designed to facilitate data migration between memory and processors, which is often more expensive in terms of power and time than the actual computational operations. Samsung says that when applied to existing HBM2 Aquabolt memory, this technology can deliver twice the system performance while reducing power consumption by more than 70%.
Another important point is that HBM-PIM does not require any changes in software or hardware (including memory controllers), which will greatly speed up and simplify the technology launch to the market. Samsung says the memory is already being tested in artificial intelligence accelerators, including with external partners. The company expects all preliminary stages to be completed in the first half of 2021.
Architecturally, each memory bank has an embedded Programmable Computing Unit (PCU) operating at 300 MHz. The memory can operate either in standard HBM2 mode or in PIM (processing-in-memory) mode for data processing. It can be noted that on the slides the technology is called FIMDRAM (function-in-memory), but the general availability will go exactly as HBM-PIM.
Apparently, the introduction of PCUs reduces the usable amount of memory – each die with a PCU has half the capacity (4 Gbps) compared to a standard HBM2 die (8 Gbps). To address this issue, Samsung is using 6GB stacks by combining four 4Gb dies with a four 8Gb dies PCU without PCU modules. Going back to HBM2, the standard stack is 8GB of eight 8Gb dies.
Kwangil Park, Senior Vice President Memory Product Planning at Samsung Electronics, said: “Our groundbreaking HBM-PIM is the industry’s first programmable PIM solution tailored for a variety of AI-driven workloads such as high performance computing, machine learning and more. AI operations. We plan to develop the technology through further partnerships with AI solution providers for advanced PIM applications. ”
The exclusive AIB partner of AMD, the Hong Kong company Sapphire Technology, has begun preparations for the announcement of flagship video cards based on the Navi 21 graphics core. The official presentation of new products will take place this Thursday, February 18, but for now the vendor has decided stir up interest the public with so-called teasers – fragmentary images of the devices being prepared for release.
Sapphire did not specify exactly which graphics solutions will be presented this week. According to foreign colleagues, the company is preparing the debut of 3D accelerators Radeon RX 6900 XT in Toxic and Atomic versions. Note that the latest video cards in these series were the Radeon R9 390 Toxic and Radeon HD 7990 Atomic, released five and eight years ago, respectively.
Judging by the teasers, the Sapphire Radeon RX 6900 XT Toxic model is based on an alternative design PCB with one 6- and two 8-pin auxiliary power connectors. Considering that the Chinese division of Sapphire is engaged in the publication of teasers, the novelty may become an exclusive solution for the Chinese market. Be that as it may, the official details of the new product will become known on Thursday.