On the one hand, it is the diseases themselves that “intervene” in the bone metabolism in various ways and can lead to a change in its micro-architecture. First and foremost, this is the general inflammation that is typical of the disease and affects not only the airways but the entire body. Dr. Funk: “It’s a very complex interaction. In addition, the mechanisms have not been clarified down to the last detail in all cases. To put it simply: The chronic inflammation caused by the lung disease, which affects the entire body, but also hypoxemia (disease-related insufficient oxygen supply to the blood) and changes in the metabolism can lead to problems in the structure of the bone. In addition, disease-related malnutrition, such as in cystic fibrosis or COPD, vitamin D deficiency plays a role. Lifestyle factors such as physical inactivity also play a role – if you have trouble breathing, you don’t like to exercise. All of these are risk factors for osteoporosis and an increased risk of bone fractures. “

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