What benefits does resveratrol promise in cancer treatment
The natural active ingredient resveratrol, found in grapes or plums, for example, is said to have numerous positive effects on health, although the scientific evidence for the hoped-for effect is often limited or completely lacking. This also applies to a possible anti-cancer effect. The potential of resveratrol in cancer therapy has now been evaluated in a recent review article.
The possible health benefits of resveratrol include a strengthening of the cardiovascular system, neurological functions or metabolism, but these effects have usually not yet been adequately scientifically proven. For example, in their study of the cardiovascular effect, researchers at the University of Alberta came to the conclusion that although resveratrol was able to protect against high blood pressure, hardening of the arteries, stroke, heart attack and heart failure in animal experiments, a corresponding effect in humans has not yet been clearly confirmed.
Researched anti-cancer effects of resveratrol
Even with the use of resveratrol for cancer treatment, the scientific evidence is so far inconclusive. With the review article that has now been published in the specialist magazine “Phytotherapy Research”, the researchers are trying to clarify this. It is clear that resveratrol, as a natural active ingredient, has shown the ability to modulate and support the immune system, the experts report.
Furthermore, the modulation of the immune system is a fundamental part of cancer therapies including immunotherapy, chemotherapy and radiation therapy. Strengthening cells of the immune system, including CD8 + T lymphocytes and natural killer cells (NK), in the fight against cancer also play a role here. Therefore, the use of active ingredients to strengthen the function of the immune system against cancer could increase the efficiency of cancer therapy.
Release of anti-cancer cytokines
The accompanying use of resveratrol is a possible option for cancer treatment, as the natural active ingredient has been shown to promote the release of anti-cancer cytokines such as IFN-γ and TNF-α and inhibit the release of certain growth factors, according to the research team. Resveratrol could also “stimulate the polarization of CD4 + T cells and macrophages against cancer cells and reduce the infiltration and polarization of immunosuppressive cells.” Last but not least, resveratrol could make cancer cells more susceptible to attacks by immune cells.
Further studies needed
“This review article explains how resveratrol can strengthen the immune system against cancer by modulating immune cell responses within the tumor,” emphasize the researchers. A concomitant use of the herbal active ingredient in cancer therapy therefore appears to be very promising. However, further research is now required, which would ultimately have to confirm the effect in clinical studies before clear treatment recommendations can be made. (fp)
Author and source information
This text complies with the requirements of specialist medical literature, medical guidelines and current studies and has been checked by medical professionals.
- Libo Chen, Ahmed Eleojo Musa: Boosting immune system against cancer by resveratrol; in: Phytotherapy Research (veröffentlicht 08.06.2021), onlinelibrary.wiley.com
- Beshay N.M. Zordoky, Ian M. Robertson, Jason R.B. Dyck: Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases; in: Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Volume 1852, Issue 6, 2015, sciencedirect.com
This article is for general guidance only and is not intended to be used for self-diagnosis or self-treatment. He can not substitute a visit at the doctor.