Live longer with reduced calorie intake – healing practice

Extend life by reducing calories

Scientific studies have shown that a strict calorie reduction die Life expectancy of animals can be extended. A new study now shows that even a moderate restriction in calorie intake helps people have relevant effects that may also affect life expectancy.

Reduced calorie intake has been shown to improve the health and longevity of laboratory animals, and recent research suggests that these benefits may extend to humans as well. The new findings are reported in the specialist journal “Immunity”.

Inflammation is reduced

In the new study, researchers at Yale University in the US show that moderate calorie restriction in humans reduces the production of a protein called SPARC. It fights harmful inflammation and improves the health of aging people.

The study, led by Vishwa Deep Dixit, director of the Yale Center for Research on Aging, follows a study published earlier this year that identified the main health benefits of moderate calorie intake in humans.

In the new study, Dixit and his co-authors analyzed additional data from the Comprehensive Assessment of Long-Term Effects of Reducing Energy Intake (CALERIE) clinical trial, in which some participants calorie intake reduced by 14 percent for two years while others ate as usual.

The researchers then tracked the long-term health effects. In particular, the scientists analyzed experimental data to identify molecules responsible for the positive effects of calorie reduction and targets for a therapeutic treatment may be

Improved metabolism

When they looked for genetic changes in the subjects’ fat tissue after one and two years, they found that those who ate fewer calories had reduced amounts of a protein called SPARC which is linked to obesity, diabetes and inflammation.

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They then looked at the effects of the protein on the immune cells and had the health of mice.

The researchers found that SPARC caused inflammation by targeting anti-inflammatory immune cells macrophagesin a pro-inflammatory state.

However, reducing SPARC production by fat cells in mice reduced inflammation, improved blood pressure metabolism and expanded their health teams as they grew older.

The results could lead to preventive measures against age-related decline in health, according to the director of the Yale Center for Research on Aging. “We now have a better understanding of how SPARC affects inflammation and health by acting on macrophages.”add Dixit added. (advertisement)

Author and source information

This text conforms to the specifications of medical specialist literature, medical guidelines and current studies and has been reviewed by medical specialists.


  • Yale University: Calorie reduction lowers protein linked to aging process, (Abruf: 15.08.2022), Yale University
  • Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit: The matricellular protein SPARC induces inflammatory interferon response in macrophages during aging; in: Immunity, (veröffentlicht: 12.08.2022), Immunity
  • Timothy W. Rhoads & Rozalyn M. Anderson: Calorie Restriction Has a New Player; in: Science, (veröffentlicht: 10.02.2022), Science

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.



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