Cristiano Ronaldo was replaced for the second consecutive game while his substitute, Paulo Dybala, scored the winning goal against AC Milan to bring Juventus back to Serie A's lead.
Head coach Maurizio Sarri made the substitution after 55 minutes. Dybala's goal placed Juve above Inter Milan.
Ronaldo, 34, has been replaced as many times in two games as he has been all season.
Juve sometimes had difficulties, Wojciech Szczesny making several good saves.
Dybala had replaced Ronaldo eight minutes from Juve's 2-1 victory over Lokomotiv Moscow in the Champions League last Wednesday.
Szczesny was busy and forced to make important stops to deny Krzysztof Piatek, Lucas Paqueta and Theo Hernandez of Milan.
Gonzalo Higuain made a tight pass for Juve and Dybala could have doubled his game late in the game.
Juve remains undefeated and one point ahead of Inter, while Milan ranks 14th.