It has been established that perfluoroalkyl substances destroy the liver. reedus

Scientists from the University of Southern California (USA) explained how synthetic polyfluoroalkyl substances (PFAS) affect the state of the human liver and what household products contain them.

PFAS, which are present in a wide range of products including non-stick cookware, carpets, waterproof clothing and fast food wrappers, were first detected in the blood of people exposed to these chemicals in the workplace in the 1970s.

This group of man-made chemicals is present in a wide range of consumer and industrial products. But what is most unpleasant of all, PFAS are slowly destroyed and accumulate in human tissues, including the liver.

Concerned about possible health effects, the researchers decided to study in detail how PFAS lead to liver damage. The scientists summarized the results of 111 peer-reviewed studies in humans and rodents and then assessed how much PFAS increased levels of the liver enzyme ALT, which is a biomarker of damage.

PFAS leads to fatty liver disease and other diseases.

© Shutterstock

After analysis, the team concluded that three of the most commonly detected PFAS in humans — perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluoronanoic acid (PFNA) — increase blood levels of ALT in both humans and rodents.

The authors noted some differences in liver injury between males and females, suggesting a mechanism for hormone dysregulation due to PFAS. In addition, these hazardous chemicals also appear to cause non-alcoholic fatty liver disease, a condition in which excess fat builds up in the liver.

Animal data show that PFAS disrupts the endocrine system, increases cholesterol, triglycerides and uric acid, which are additional biomarkers of metabolic disorders.

A fast food wrapper contains a large amount of

Fast food wrappers contain a large amount of polyfluoroalkyl substances.

© Pinterest

As the authors note, despite the research findings, the problem with PFAS is that people are exposed to mixtures of hundreds, if not thousands, of these chemicals. Therefore, it is often very difficult to determine exactly which particular substance seriously damages the liver.

In addition, due to the longevity of PFAS, they end up in drinking water and many foods, so even if these substances are abruptly phased out, a significant part of them will remain in the environment.

Therefore, the authors of the study emphasize that it is necessary to clean up the sources of exposure to PFAS in the coming years, as well as seriously think about the treatment of people who are regularly exposed to high doses of these substances. Moreover, according to a recent discovery, PFAS also potentially cause diabetes.



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