How the gut microbiome affects the course of heart failure
A lack Diversity of microorganisms in the gut According to a current review, the course of Heart failure (heart failure) influence negatively. sick with one gut flora out of balance must therefore more often to the hospital be admitted and have a increased risk of death because of the heart disease.
researchers of Georgetown University Medical Center in Washington DC (USA) have compiled evidence from over 500 studies demonstrating that a lower biodiversity of microorganisms in the intestine With more severe courses of heart failure connected is. The results of the review were recently presented in the journal Heart Failure Reviews.
The gut houses an entire ecosystem
Our Darmmikrobiomoften as “Darmflora“, is a finely balanced ecosystem that consists mainly of many different types of bacteria. In addition, various viruses, fungi and protozoa also settle in the intestine.
Previous studies have already shown that the intestinal flora central role in human health plays. The metabolic products that the intestinal bacteria produce are needed by the body to stay healthy.
The intestinal flora is even connected to the brain via the so-called gut-brain axis. The working group at Georgetown University Medical Center has now shown that the microbiome in the intestine also affects the Course of cardiovascular diseases can affect.
Intestinal flora is not considered enough in medicine
“We rely on certain findings and test results to diagnose and treat heart failure, but we don’t know how poor heart function affects the activities of the gut”explains the corresponding study author Professorin Dr. Kelley Anderson.
According to her, it has not yet been taken into account how ingested food and medication change the intestinal flora and how a change in the intestinal flora affects the course of the disease.
Interactions between intestinal flora and the cardiovascular system
“There is now an understanding of an interrelated relationship between the heart and elements in the gut, since the heart and vasculature clearly do not function in isolation”emphasizes Professorin Anderson.
The health of the cardiovascular system can influence the health of the intestinal flora and vice versa. The clear evidence for this is currently being worked out in current studies.
Link suggested in 511 studies
In recent years, more advanced technologies have made it possible to better understand the complex relationship between microorganisms in the gut and human health.
The team collected and evaluated 511 research articles, which were released between the years 2014 and 2021. In all articles, a Relationship between the gut microbiome and heart health suggested. The scientists found 30 studies with special relevance.
Effects of certain metabolites of intestinal bacteria
An example of the link is a metabolite called Trimethylamine-N-Oxid (TMAO) – a metabolite of certain gut bacteria that can affect cardiovascular health.
TMAO is increased when Consumption of whole milk products, egg yolks and red meat produced if one imbalanced intestinal flora present.
Diet affects gut flora and heart health
The researchers emphasize that the nutrition is an important part of overall cardiovascular health. The composition of the intestinal microbiome is also influenced by nutrition.
However, the subtleties of this interaction are not yet sufficiently understood. according to dr Anderson are currently running studies examining how the use of Antibiotics, prebiotics and probiotics affects the microbiome in the gut.
Read the severity of heart disease from the intestinal flora
Overall, the working group sees great potential in influencing the intestinal flora for the treatment of heart diseases such as cardiac insufficiency.
“We are currently developing a pioneering study to assess the microbiome in patients with heart failure”, emphasizes the study author. (vb)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Graduate editor (FH) Volker Blasek
- Georgetown University Medical Center: Lack of diversity of micro-organisms in the gut or elevated metabolite implicated in heart failure severity (veröffentlicht: 20.06.2022), eurekalert.org
- Kelley M. Anderson, Erin P. Ferranti, Emily Couvillon Alagha, et al.: The heart and gut relationship: a systematic review of the evaluation of the microbiome and trimethylamine-N-oxide (TMAO) in heart failure; in: Heart Failure Reviews (2022), link.springer.com
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.