University of Connecticut scientists have discovered that removing old cells in human adipose tissue reduces the signs of type 2 diabetes.
The journal Cell Metabolism notes that the new method will help treat various metabolic diseases.
The body’s cells are also known to be in constant renewal. But this mechanism sometimes stops, which leads to the accumulation of old, aging cells in the tissues, which affect their surroundings, through distorted molecular signals, which leads to the malabsorption of nutrients such as sugar by the cells, causing a pre-diabetic state.
Researchers have created and tested a combination of experimental preparations such as dasatinib and quercetin, and it turns out that they extend life and improve the health of elderly mice.
According to the results obtained by the researchers, the two drugs can combat old cells in cultures of human adipose tissue, which were injected into mice, which disrupted their metabolism. But after being treated with dasatinib and quercetin, the harmful effects of adipose tissue practically disappeared.
The researchers analyzed a population of aged cells expressing an elevated level of p21 – an inhibitor of cyclin-dependent kinases and one of the key markers of cell aging. And it became clear to them that cleansing the body of old cells once a month has an effective effect in slowing the development of diabetes, as well as in relieving the symptoms of diabetes that appeared in mice that suffer from excess weight.
Source: linta. Ro